UniProt functional annotation for Q8MU52

UniProt code: Q8MU52.

Organism: Plasmodium falciparum.
Taxonomy: Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodium; Plasmodium (Laverania).
 
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin).
 
Catalytic activity: RX + glutathione = HX + R-S-glutathione.
Enzyme regulation: Inhibited by chloroquine, cibacron blue, ferriprotoporphyrin IX (hemin) and S-hexylglutathione.
Biophysicochemical properties: Kinetic parameters: KM=0.156 mM for bromosulphophthalein; KM=10 mM for 1-chloro-2,4-dinitrobenzene; KM=2.5 mM for 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole; KM=0.96 mM for ethacrynic acid; KM=0.164 mM for reduced glutathione; pH dependence: Optimum pH is 8.1;
Subunit: Homodimer. In the absence of ligands two homodimers may interact to form a tetramer.
Similarity: Belongs to the GST superfamily.
Similarity: Contains 1 GST C-terminal domain.
Similarity: Contains 1 GST N-terminal domain.

Annotations taken from UniProtKB at the EBI.