UniProt functional annotation for P31224

UniProt code: P31224.

Organism: Escherichia coli (strain K12).
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Function: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. {ECO:0000269|PubMed:16915237, ECO:0000269|PubMed:16946072, ECO:0000269|PubMed:17194213, ECO:0000269|PubMed:23010927}.
Subunit: Homotrimer, with large domains that extend into the periplasm, interacts with AcrA and TolC. AcrA may be required to stably link this protein and TolC. Interacts with AcrZ. Part of the AcrA-AcrB-AcrZ-TolC efflux pump. {ECO:0000269|PubMed:10920254, ECO:0000269|PubMed:12374972, ECO:0000269|PubMed:12738864, ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:16915237, ECO:0000269|PubMed:16946072, ECO:0000269|PubMed:17194213, ECO:0000269|PubMed:23010927}.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}; Multi- pass membrane protein {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}.
Induction: Positively regulated by MarA, Rob and SoxS transcriptional regulators (at protein level). {ECO:0000269|PubMed:23010927}.
Similarity: Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.