UniProt functional annotation for Q97UY8



	UniProt functional annotation for Q97UY8

UniProt code: Q97UY8.

Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus).

Taxonomy: Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus.

Function: Part of the ABC transporter complex GlcSTUV involved in glucose uptake (Probable). Responsible for energy coupling to the transport system (PubMed:12823973, PubMed:14607117). In vitro, as a free subunit, exhibits a constitutive ATPase activity (PubMed:11807278). {ECO:0000269|PubMed:11807278, ECO:0000269|PubMed:12823973, ECO:0000269|PubMed:14607117, ECO:0000305|PubMed:10400586, ECO:0000305|PubMed:11260467}.

Catalytic activity: Reaction=ATP + D-glucose(out) + H2O = ADP + D-glucose(in) + H(+) + phosphate; Xref=Rhea:RHEA:60184, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000305|PubMed:10400586}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60185; Evidence={ECO:0000305|PubMed:10400586};

Biophysicochemical properties: Kinetic parameters: KM=290 uM for ATP {ECO:0000269|PubMed:11807278}; pH dependence: Optimum pH is 6.5 for ATPase activity. {ECO:0000269|PubMed:11807278};

Subunit: The complex is composed of two ATP-binding proteins (GlcV), two transmembrane proteins (GlcT and GlcU) and a solute-binding protein (GlcS) (Probable). Forms transient head-to-tail homodimers in the presence of ATP-Mg(2+) (PubMed:14607117). {ECO:0000269|PubMed:14607117, ECO:0000305|PubMed:10400586}.

Subcellular location: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.

Domain: Consists of a typical ABC-ATPase domain, comprising two subdomains, connected by a linker region to a C-terminal domain of unknown function. {ECO:0000269|PubMed:12823973}.

Similarity: Belongs to the ABC transporter superfamily.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus).
Taxonomy:		Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus.



Function:		Part of the ABC transporter complex GlcSTUV involved in glucose uptake (Probable). Responsible for energy coupling to the transport system (PubMed:12823973, PubMed:14607117). In vitro, as a free subunit, exhibits a constitutive ATPase activity (PubMed:11807278). {ECO:0000269\|PubMed:11807278, ECO:0000269\|PubMed:12823973, ECO:0000269\|PubMed:14607117, ECO:0000305\|PubMed:10400586, ECO:0000305\|PubMed:11260467}.


Catalytic activity:		Reaction=ATP + D-glucose(out) + H2O = ADP + D-glucose(in) + H(+) + phosphate; Xref=Rhea:RHEA:60184, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000305\|PubMed:10400586}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60185; Evidence={ECO:0000305\|PubMed:10400586};
Biophysicochemical properties:		Kinetic parameters: KM=290 uM for ATP {ECO:0000269\|PubMed:11807278}; pH dependence: Optimum pH is 6.5 for ATPase activity. {ECO:0000269\|PubMed:11807278};
Subunit:		The complex is composed of two ATP-binding proteins (GlcV), two transmembrane proteins (GlcT and GlcU) and a solute-binding protein (GlcS) (Probable). Forms transient head-to-tail homodimers in the presence of ATP-Mg(2+) (PubMed:14607117). {ECO:0000269\|PubMed:14607117, ECO:0000305\|PubMed:10400586}.
Subcellular location:		Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Domain:		Consists of a typical ABC-ATPase domain, comprising two subdomains, connected by a linker region to a C-terminal domain of unknown function. {ECO:0000269\|PubMed:12823973}.
Similarity:		Belongs to the ABC transporter superfamily.