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PDBsum entry 1orq

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protein metals Protein-protein interface(s) links
Membrane protein PDB id
1orq
Jmol PyMol
Contents
Protein chains
215 a.a. *
219 a.a. *
223 a.a. *
Metals
_CD ×7
__K ×6
Waters ×6
* Residue conservation analysis
PDB id:
1orq
Name: Membrane protein
Title: X-ray structure of a voltage-dependent potassium channel in with an fab
Structure: 6e1 fab light chain. Chain: a. 6e1 fab heavy chain. Chain: b. Potassium channel. Chain: c. Fragment: kvap. Engineered: yes. Mutation: yes
Source: Mus musculus. House mouse. Organism_taxid: 10090. Other_details: mouse hybridoma. Aeropyrum pernix. Organism_taxid: 56636. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dodecamer (from PDB file)
Resolution:
3.20Å     R-factor:   0.253     R-free:   0.298
Authors: Y.Jiang,A.Lee,J.Chen,V.Ruta,M.Cadene,B.T.Chait,R.Mackinnon
Key ref:
Y.Jiang et al. (2003). X-ray structure of a voltage-dependent K+ channel. Nature, 423, 33-41. PubMed id: 12721618 DOI: 10.1038/nature01580
Date:
14-Mar-03     Release date:   06-May-03    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P01837  (IGKC_MOUSE) -  Ig kappa chain C region
Seq:
Struc:
106 a.a.
215 a.a.
Protein chain
Pfam   ArchSchema ?
P01865  (GCAM_MOUSE) -  Ig gamma-2A chain C region, membrane-bound form
Seq:
Struc:
398 a.a.
219 a.a.*
Protein chain
Pfam   ArchSchema ?
Q9YDF8  (KVAP_AERPE) -  Voltage-gated potassium channel
Seq:
Struc:
295 a.a.
223 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     blood microparticle   6 terms 
  Biological process     transmembrane transport   11 terms 
  Biochemical function     antigen binding     4 terms  

 

 
DOI no: 10.1038/nature01580 Nature 423:33-41 (2003)
PubMed id: 12721618  
 
 
X-ray structure of a voltage-dependent K+ channel.
Y.Jiang, A.Lee, J.Chen, V.Ruta, M.Cadene, B.T.Chait, R.MacKinnon.
 
  ABSTRACT  
 
Voltage-dependent K+ channels are members of the family of voltage-dependent cation (K+, Na+ and Ca2+) channels that open and allow ion conduction in response to changes in cell membrane voltage. This form of gating underlies the generation of nerve and muscle action potentials, among other processes. Here we present the structure of KvAP, a voltage-dependent K+ channel from Aeropyrum pernix. We have determined a crystal structure of the full-length channel at a resolution of 3.2 A, and of the isolated voltage-sensor domain at 1.9 A, both in complex with monoclonal Fab fragments. The channel contains a central ion-conduction pore surrounded by voltage sensors, which form what we call 'voltage-sensor paddles'-hydrophobic, cationic, helix-turn-helix structures on the channel's outer perimeter. Flexible hinges suggest that the voltage-sensor paddles move in response to membrane voltage changes, carrying their positive charge across the membrane.
 
  Selected figure(s)  
 
Figure 3.
Figure 3: Architecture of the KvAP channel. a, Stereo image of the KvAP channel tetramer viewed from the intracellular side of the membrane. Each subunit is a different colour; helical elements of the blue subunit are labelled numerically for S1 -S6 and with P for the pore helix. N and C mark the termini. b, Stereo image of the KvAP channel tetramer viewed from the side with the intracellular solution below. Views in a and b are related by a 90 rotation about a horizontal axis. Side chains of selected residues known to be involved in voltage-dependent gating are shown on the blue and red subunits. Selected helical elements are labelled on the red and blue subunits. c, A single KvAP subunit viewed from the same perspective as in b. Conserved arginine residues on the voltage-sensor paddle are shown. d, A schematic diagram of the KvAP subunit topology is shown with an orange selectivity filter and an arrow to indicate the ion pathway. The demarcation between the S4 -S5 linker and S5 is indicated by a black line.
Figure 7.
Figure 7: Effect of Fabs on voltage-sensor conformation. a, Stereo view of two subunits (blue and red) from the full-length channel viewed from the side with the intracellular solution below. b, Identical view of the pore (S5 -S6) with the isolated voltage sensor docked according to the position of S2 in the full-length channel. The Asp 62 -Arg 133 salt bridge is shown.
 
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nature (2003, 423, 33-41) copyright 2003.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
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PDB code: 2kyh
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PDB code: 3inu
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PDB code: 2ogu
17588940 M.M.Kuo, Y.Saimi, C.Kung, and S.Choe (2007).
Patch clamp and phenotypic analyses of a prokaryotic cyclic nucleotide-gated K+ channel using Escherichia coli as a host.
  J Biol Chem, 282, 24294-24301.  
  17938232 M.Milescu, J.Vobecky, S.H.Roh, S.H.Kim, H.J.Jung, J.I.Kim, and K.J.Swartz (2007).
Tarantula toxins interact with voltage sensors within lipid membranes.
  J Gen Physiol, 130, 497-511.  
17367718 M.Punta, L.R.Forrest, H.Bigelow, A.Kernytsky, J.Liu, and B.Rost (2007).
Membrane protein prediction methods.
  Methods, 41, 460-474.  
17884814 M.Semtner, M.Schaefer, O.Pinkenburg, and T.D.Plant (2007).
Potentiation of TRPC5 by protons.
  J Biol Chem, 282, 33868-33878.  
  17296928 O.M.Koval, Y.Fan, and B.S.Rothberg (2007).
A role for the S0 transmembrane segment in voltage-dependent gating of BK channels.
  J Gen Physiol, 129, 209-220.  
17301243 P.J.Bond, and M.S.Sansom (2007).
Bilayer deformation by the Kv channel voltage sensor domain revealed by self-assembly simulations.
  Proc Natl Acad Sci U S A, 104, 2631-2636.  
17444521 P.J.Stansfeld, P.Gedeck, M.Gosling, B.Cox, J.S.Mitcheson, and M.J.Sutcliffe (2007).
Drug block of the hERG potassium channel: insight from modeling.
  Proteins, 68, 568-580.  
17850745 P.L.Chiu, M.D.Pagel, J.Evans, H.T.Chou, X.Zeng, B.Gipson, H.Stahlberg, and C.M.Nimigean (2007).
The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution.
  Structure, 15, 1053-1064.  
17723294 R.K.Hite, S.Raunser, and T.Walz (2007).
Revival of electron crystallography.
  Curr Opin Struct Biol, 17, 389-395.  
17823114 R.M.Hardman, P.J.Stansfeld, S.Dalibalta, M.J.Sutcliffe, and J.S.Mitcheson (2007).
Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.
  J Biol Chem, 282, 31972-31981.  
18004376 S.B.Long, X.Tao, E.B.Campbell, and R.MacKinnon (2007).
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.
  Nature, 450, 376-382.
PDB code: 2r9r
  17938230 S.Chakrapani, J.F.Cordero-Morales, and E.Perozo (2007).
A quantitative description of KcsA gating I: macroscopic currents.
  J Gen Physiol, 130, 465-478.  
  17438116 S.H.White (2007).
Membrane protein insertion: the biology-physics nexus.
  J Gen Physiol, 129, 363-369.  
17962407 S.Nauli, S.Farr, Y.J.Lee, H.Y.Kim, S.Faham, and J.U.Bowie (2007).
Polymer-driven crystallization.
  Protein Sci, 16, 2542-2551.
PDB codes: 2qar 2qb0 2qb1
17513348 S.Varma, and S.B.Rempe (2007).
Tuning ion coordination architectures to enable selective partitioning.
  Biophys J, 93, 1093-1099.  
  17893194 T.Cens, M.Rousset, A.Kajava, and P.Charnet (2007).
Molecular determinant for specific Ca/Ba selectivity profiles of low and high threshold Ca2+ channels.
  J Gen Physiol, 130, 415-425.  
17197439 V.Chubanov, K.P.Schlingmann, J.Wäring, J.Heinzinger, S.Kaske, S.Waldegger, M.M.Schnitzler, and T.Gudermann (2007).
Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of TRPM6.
  J Biol Chem, 282, 7656-7667.  
17704179 V.Jogini, and B.Roux (2007).
Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment.
  Biophys J, 93, 3070-3082.  
17693406 V.P.Pau, Y.Zhu, Z.Yuchi, Q.Q.Hoang, and D.S.Yang (2007).
Characterization of the C-terminal domain of a potassium channel from Streptomyces lividans (KcsA).
  J Biol Chem, 282, 29163-29169.  
17534481 X.Liang, D.J.Campopiano, and P.J.Sadler (2007).
Metals in membranes.
  Chem Soc Rev, 36, 968-992.  
17347852 Y.Okamura (2007).
Biodiversity of voltage sensor domain proteins.
  Pflugers Arch, 454, 361-371.  
17292841 Z.A.Sands, and M.S.Sansom (2007).
How does a voltage sensor interact with a lipid bilayer? Simulations of a potassium channel domain.
  Structure, 15, 235-244.  
18042709 Z.Su, X.Zhou, W.J.Haynes, S.H.Loukin, A.Anishkin, Y.Saimi, and C.Kung (2007).
Yeast gain-of-function mutations reveal structure-function relationships conserved among different subfamilies of transient receptor potential channels.
  Proc Natl Acad Sci U S A, 104, 19607-19612.  
  16735758 A.A.Fodor, and R.W.Aldrich (2006).
Statistical limits to the identification of ion channel domains by sequence similarity.
  J Gen Physiol, 127, 755-766.  
17136097 A.G.Lee (2006).
Ion channels: a paddle in oil.
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17008310 A.Lampert, S.D.Dib-Hajj, L.Tyrrell, and S.G.Waxman (2006).
Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating.
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  16908726 A.Lundby, J.S.Santos, C.Zazueta, and M.Montal (2006).
Molecular template for a voltage sensor in a novel K+ channel. II. Conservation of a eukaryotic sensor fold in a prokaryotic K+ channel.
  J Gen Physiol, 128, 293-300.  
16538695 A.Mourot, T.Grutter, M.Goeldner, and F.Kotzyba-Hibert (2006).
Dynamic structural investigations on the torpedo nicotinic acetylcholine receptor by time-resolved photoaffinity labeling.
  Chembiochem, 7, 570-583.  
17038321 A.Raybaud, Y.Dodier, P.Bissonnette, M.Simoes, D.G.Bichet, R.Sauvé, and L.Parent (2006).
The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels.
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16877518 A.Rosenhouse-Dantsker, and D.E.Logothetis (2006).
New roles for a key glycine and its neighboring residue in potassium channel gating.
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17098190 A.W.Van Wynsberghe, and Q.Cui (2006).
Interpreting correlated motions using normal mode analysis.
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17216034 B.Corry (2006).
Understanding ion channel selectivity and gating and their role in cellular signalling.
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17114039 B.Roux (2006).
Dissecting the coupling between the voltage sensor and pore domains.
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  16735753 B.Zadek, and C.M.Nimigean (2006).
Calcium-dependent gating of MthK, a prokaryotic potassium channel.
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17206516 C.C.Quinn, and T.Begenisich (2006).
Pharmacology and surface electrostatics of the K channel outer pore vestibule.
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16828280 C.G.Tate (2006).
Comparison of three structures of the multidrug transporter EmrE.
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17406403 C.M.Nimigean (2006).
A radioactive uptake assay to measure ion transport across ion channel-containing liposomes.
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  16940557 C.M.Wilkens, and R.W.Aldrich (2006).
State-independent block of BK channels by an intracellular quaternary ammonium.
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16645081 C.Miller (2006).
Biophysics. Lonely voltage sensor seeks protons for permeation.
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16738606 D.L.Minor (2006).
A sensitive channel family replete with sense and motion.
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17002665 D.P.Tieleman (2006).
Computer simulations of transport through membranes: passive diffusion, pores, channels and transporters.
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17136096 D.Schmidt, Q.X.Jiang, and R.MacKinnon (2006).
Phospholipids and the origin of cationic gating charges in voltage sensors.
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16530414 D.Shental-Bechor, S.J.Fleishman, and N.Ben-Tal (2006).
Has the code for protein translocation been broken?
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16903835 D.V.Mamaev, D.A.Aliverdieva, D.I.Bondarenko, and K.F.Sholtz (2006).
Study of active site topography of rat liver mitochondrial dicarboxylate transporter using lipophilic substrate derivatives.
  Biochemistry (Mosc), 71, 800-809.  
16690619 E.Kobrinsky, L.Stevens, Y.Kazmi, D.Wray, and N.M.Soldatov (2006).
Molecular rearrangements of the Kv2.1 potassium channel termini associated with voltage gating.
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16493417 E.Perozo (2006).
Gating prokaryotic mechanosensitive channels.
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16704338 F.Tombola, M.M.Pathak, and E.Y.Isacoff (2006).
How does voltage open an ion channel?
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Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.
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16326905 G.Seebohm, N.Strutz-Seebohm, O.N.Ureche, R.Baltaev, A.Lampert, G.Kornichuk, K.Kamiya, T.V.Wuttke, H.Lerche, M.C.Sanguinetti, and F.Lang (2006).
Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.
  Biophys J, 90, 2235-2244.  
16533837 H.Sackin, M.Nanazashvili, L.G.Palmer, and H.Li (2006).
Role of conserved glycines in pH gating of Kir1.1 (ROMK).
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16892366 H.Sun (2006).
An accurate and interpretable bayesian classification model for prediction of HERG liability.
  ChemMedChem, 1, 315-322.  
  16606689 H.T.Kurata, L.J.Marton, and C.G.Nichols (2006).
The polyamine binding site in inward rectifier K+ channels.
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17015441 I.Dragoni, E.Guida, and P.McIntyre (2006).
The cold and menthol receptor TRPM8 contains a functionally important double cysteine motif.
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16533848 I.H.Shrivastava, and I.Bahar (2006).
Common mechanism of pore opening shared by five different potassium channels.
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16623889 I.Johansson, K.Wulfetange, F.Porée, E.Michard, P.Gajdanowicz, B.Lacombe, H.Sentenac, J.B.Thibaud, B.Mueller-Roeber, M.R.Blatt, and I.Dreyer (2006).
External K+ modulates the activity of the Arabidopsis potassium channel SKOR via an unusual mechanism.
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16907122 I.S.Tolokh, S.Goldman, and C.G.Gray (2006).
Unified modeling of conductance kinetics for low- and high-conductance potassium ion channels.
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17012321 J.A.Freites, D.J.Tobias, and S.H.White (2006).
A voltage-sensor water pore.
  Biophys J, 91, L90-L92.  
16997865 J.B.Saenen, A.J.Labro, A.Raes, and D.J.Snyders (2006).
Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.
  Biophys J, 91, 4381-4391.  
16532008 J.F.Cordero-Morales, L.G.Cuello, and E.Perozo (2006).
Voltage-dependent gating at the KcsA selectivity filter.
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16532009 J.F.Cordero-Morales, L.G.Cuello, Y.Zhao, V.Jogini, D.M.Cortes, B.Roux, and E.Perozo (2006).
Molecular determinants of gating at the potassium-channel selectivity filter.
  Nat Struct Mol Biol, 13, 311-318.
PDB codes: 1zwi 2atk
16522799 J.H.Chill, J.M.Louis, C.Miller, and A.Bax (2006).
NMR study of the tetrameric KcsA potassium channel in detergent micelles.
  Protein Sci, 15, 684-698.  
  17130521 J.M.Rocheleau, S.D.Gage, and W.R.Kobertz (2006).
Secondary structure of a KCNE cytoplasmic domain.
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17043236 J.Richardson, R.Blunck, P.Ge, P.R.Selvin, F.Bezanilla, D.M.Papazian, and A.M.Correa (2006).
Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer.
  Proc Natl Acad Sci U S A, 103, 15865-15870.  
  16908725 J.S.Santos, A.Lundby, C.Zazueta, and M.Montal (2006).
Molecular template for a voltage sensor in a novel K+ channel. I. Identification and functional characterization of KvLm, a voltage-gated K+ channel from Listeria monocytogenes.
  J Gen Physiol, 128, 283-292.  
16850015 K.J.Swartz (2006).
Greasing the gears of potassium channels.
  Nat Chem Biol, 2, 401-402.  
16955311 K.Talavera, and B.Nilius (2006).
Evidence for common structural determinants of activation and inactivation in T-type Ca2+ channels.
  Pflugers Arch, 453, 189-201.  
16506891 K.W.Chaudhary, J.M.O'Neal, Z.L.Mo, B.Fermini, R.H.Gallavan, and A.Bahinski (2006).
Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.
  Assay Drug Dev Technol, 4, 73-82.  
16609771 L.A.Clapp, C.J.Siddons, D.G.VanDerveer, J.H.Reibenspies, S.B.Jones, and R.D.Hancock (2006).
The amide oxygen donor. Metal ion coordinating properties of the ligand nitrilotriacetamide. A thermodynamic and crystallographic study.
  Dalton Trans, (), 2001-2007.  
16720570 L.Cohen, N.Gilles, I.Karbat, N.Ilan, D.Gordon, and M.Gurevitz (2006).
Direct evidence that receptor site-4 of sodium channel gating modifiers is not dipped in the phospholipid bilayer of neuronal membranes.
  J Biol Chem, 281, 20673-20679.  
17159147 L.Li, D.Mustafi, Q.Fu, V.Tereshko, D.L.Chen, J.D.Tice, and R.F.Ismagilov (2006).
Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins.
  Proc Natl Acad Sci U S A, 103, 19243-19248.
PDB code: 2i5n
16761093 L.X.Liu, M.L.Li, F.Y.Tan, M.C.Lu, K.L.Wang, Y.Z.Guo, Z.N.Wen, and L.Jiang (2006).
Local sequence information-based support vector machine to classify voltage-gated potassium channels.
  Acta Biochim Biophys Sin (Shanghai), 38, 363-371.  
16520735 M.Bandell, A.E.Dubin, M.J.Petrus, A.Orth, J.Mathur, S.W.Hwang, and A.Patapoutian (2006).
High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol.
  Nat Neurosci, 9, 493-500.  
16554806 M.C.Sanguinetti, and M.Tristani-Firouzi (2006).
hERG potassium channels and cardiac arrhythmia.
  Nature, 440, 463-469.  
16932562 M.G.Hanna (2006).
Genetic neurological channelopathies.
  Nat Clin Pract Neurol, 2, 252-263.  
16835240 M.Iwamoto, H.Shimizu, F.Inoue, T.Konno, Y.C.Sasaki, and S.Oiki (2006).
Surface structure and its dynamic rearrangements of the KcsA potassium channel upon gating and tetrabutylammonium blocking.
  J Biol Chem, 281, 28379-28386.  
16283201 M.L.Chapman, M.L.Blanke, H.S.Krovetz, and A.M.Vandongen (2006).
Allosteric effects of external K(+) ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K(+) channel.
  Pflugers Arch, 451, 776-792.  
16336510 M.R.Rosen, and I.S.Cohen (2006).
Molecular/genetic determinants of repolarization and their modification by environmental stress.
  J Intern Med, 259, 7.  
16792699 N.L.Brooks, M.J.Corey, and R.A.Schwalbe (2006).
Characterization of N-glycosylation consensus sequences in the Kv3.1 channel.
  FEBS J, 273, 3287-3300.  
16912051 O.B.Kashlan, A.B.Maarouf, C.Kussius, R.M.Denshaw, K.M.Blumenthal, and T.R.Kleyman (2006).
Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel.
  J Biol Chem, 281, 30455-30462.  
16863470 P.J.Stansfeld, M.J.Sutcliffe, and J.S.Mitcheson (2006).
Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.
  Expert Opin Drug Metab Toxicol, 2, 81-94.  
17139282 P.Stanfield (2006).
Voltage sparks a GPCR.
  Nat Cell Biol, 8, 1323-1325.  
  17101817 R.B.Darman, A.A.Ivy, V.Ketty, and R.O.Blaustein (2006).
Constraints on voltage sensor movement in the shaker K+ channel.
  J Gen Physiol, 128, 687-699.  
  17043150 R.Blunck, J.F.Cordero-Morales, L.G.Cuello, E.Perozo, and F.Bezanilla (2006).
Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction.
  J Gen Physiol, 128, 569-581.  
16532364 R.C.Capeta, J.A.Poveda, and L.M.Loura (2006).
Non-uniform membrane probe distribution in resonance energy transfer: application to protein-lipid selectivity.
  J Fluoresc, 16, 161-172.  
16679310 S.Cestèle, V.Yarov-Yarovoy, Y.Qu, F.Sampieri, T.Scheuer, and W.A.Catterall (2006).
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.
  J Biol Chem, 281, 21332-21344.  
16877513 S.Furini, F.Zerbetto, and S.Cavalcanti (2006).
Application of the Poisson-Nernst-Planck theory with space-dependent diffusion coefficients to KcsA.
  Biophys J, 91, 3162-3169.  
16472864 S.I.Judge, and C.T.Bever (2006).
Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment.
  Pharmacol Ther, 111, 224-259.  
16406532 S.J.Fleishman, V.M.Unger, and N.Ben-Tal (2006).
Transmembrane protein structures without X-rays.
  Trends Biochem Sci, 31, 106-113.  
16272446 S.S.Deol, C.Domene, P.J.Bond, and M.S.Sansom (2006).
Anionic phospholipid interactions with the potassium channel KcsA: simulation studies.
  Biophys J, 90, 822-830.  
  16946459 T.P.Roosild, S.Castronovo, and S.Choe (2006).
Structure of anti-FLAG M2 Fab domain and its use in the stabilization of engineered membrane proteins.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 62, 835-839.
PDB code: 2g60
16989594 T.V.Wuttke, and H.Lerche (2006).
Novel anticonvulsant drugs targeting voltage-dependent ion channels.
  Expert Opin Investig Drugs, 15, 1167-1177.  
16648251 V.Yarov-Yarovoy, D.Baker, and W.A.Catterall (2006).
Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels.
  Proc Natl Acad Sci U S A, 103, 7292-7297.  
  16966472 W.Li, and R.W.Aldrich (2006).
State-dependent block of BK channels by synthesized shaker ball peptides.
  J Gen Physiol, 128, 423-441.  
16980355 W.Treptow, and M.Tarek (2006).
K+ conduction in the selectivity filter of potassium channels is monitored by the charge distribution along their sequence.
  Biophys J, 91, L81-L83.  
  16940555 X.Zhang, X.Zeng, and C.J.Lingle (2006).
Slo3 K+ channels: voltage and pH dependence of macroscopic currents.
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16807902 Y.Park, and V.Helms (2006).
Assembly of transmembrane helices of simple polytopic membrane proteins from sequence conservation patterns.
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16326912 Z.A.Sands, A.Grottesi, and M.S.Sansom (2006).
The intrinsic flexibility of the Kv voltage sensor and its implications for channel gating.
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  16505150 Z.Ma, X.J.Lou, and F.T.Horrigan (2006).
Role of charged residues in the S1-S4 voltage sensor of BK channels.
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15574706 A.C.Saladino, Y.Xu, and P.Tang (2005).
Homology modeling and molecular dynamics simulations of transmembrane domain structure of human neuronal nicotinic acetylcholine receptor.
  Biophys J, 88, 1009-1017.  
15951376 A.Giorgetti, P.Carloni, P.Mistrik, and V.Torre (2005).
A homology model of the pore region of HCN channels.
  Biophys J, 89, 932-944.  
15816177 A.Grottesi, C.Domene, S.Haider, and M.S.Sansom (2005).
Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.
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16169480 A.Grottesi, Z.A.Sands, and M.S.Sansom (2005).
Potassium channels: complete and undistorted.
  Curr Biol, 15, R771-R774.  
  15623896 A.J.Labro, A.L.Raes, and D.J.Snyders (2005).
Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels.
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16091360 A.K.Bera, and M.H.Akabas (2005).
Spontaneous thermal motion of the GABA(A) receptor M2 channel-lining segments.
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16001276 A.M.Scharenberg (2005).
TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors.
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16113115 A.Mitra, R.Tascione, A.Auerbach, and S.Licht (2005).
Plasticity of acetylcholine receptor gating motions via rate-energy relationships.
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15711166 A.Pohorille, K.Schweighofer, and M.A.Wilson (2005).
The origin and early evolution of membrane channels.
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Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement.
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16111489 B.Li, and W.J.Gallin (2005).
Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channels.
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Ion conduction and selectivity in K(+) channels.
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16202706 C.A.Ahern, and R.Horn (2005).
Focused electric field across the voltage sensor of potassium channels.
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15774578 C.Gonzalez, F.J.Morera, E.Rosenmann, O.Alvarez, and R.Latorre (2005).
S3b amino acid residues do not shuttle across the bilayer in voltage-dependent Shaker K+ channels.
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16043238 C.S.Gandhi, and E.Y.Isacoff (2005).
Shedding light on membrane proteins.
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  16129771 C.Xie, X.G.Zhen, and J.Yang (2005).
Localization of the activation gate of a voltage-gated Ca2+ channel.
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16004681 D.DiFrancesco (2005).
Cardiac pacemaker I(f) current and its inhibition by heart rate-reducing agents.
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15975984 D.Fernandez, A.Ghanta, K.I.Kinard, and M.C.Sanguinetti (2005).
Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation.
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16094368 D.J.Posson, P.Ge, C.Miller, F.Bezanilla, and P.R.Selvin (2005).
Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer.
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16084381 D.L.Minor (2005).
Bend to open?
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Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating.
  J Biol Chem, 280, 7206-7217.  
15836254 E.Jarkova, T.J.Vlugt, and N.K.Lee (2005).
Stretching a heteropolymer.
  J Chem Phys, 122, 114904.  
16297070 E.Michard, I.Dreyer, B.Lacombe, H.Sentenac, and J.B.Thibaud (2005).
Inward rectification of the AKT2 channel abolished by voltage-dependent phosphorylation.
  Plant J, 44, 783-797.  
16237035 E.Vardy, S.Steiner-Mordoch, and S.Schuldiner (2005).
Characterization of bacterial drug antiporters homologous to mammalian neurotransmitter transporters.
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15816170 F.Bezanilla (2005).
Voltage-gated ion channels.
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