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UniProt functional annotation for Q9I8X1 | ||
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| UniProt code: Q9I8X1. |
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| Organism: | |
Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Deinagkistrodon. |
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| Function: | |
Snake venom serine protease that has fibrinogenolytic activities. Also possess esterolysis and amidolytic activities. Selectively cleaves Arg-|-Xaa bonds. {ECO:0000269|PubMed:12595722, ECO:0000269|PubMed:15632114}. |
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| Activity regulation: | |
Inhibited by NPGB, leupeptin, aprotinin and PMSF, but not by EDTA, SBTI, heparin and hirudin. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=0.152 uM for TAME {ECO:0000269|PubMed:12595722, ECO:0000269|PubMed:15632114}; KM=265 uM for D-Phe-L-Pip-Arg-p-NA (S-2238) {ECO:0000269|PubMed:12595722, ECO:0000269|PubMed:15632114}; KM=113 uM for D-Pro-Phe-Arg-p-NA (S-2302) {ECO:0000269|PubMed:12595722, ECO:0000269|PubMed:15632114}; KM=28 uM for N-p-Tosyl-Gly-Pro-Arg-p-NA {ECO:0000269|PubMed:12595722, ECO:0000269|PubMed:15632114}; KM=202 uM for N-p-Tosyl-Gly-Pro-Lys-p-NA {ECO:0000269|PubMed:12595722, ECO:0000269|PubMed:15632114}; Note=AaV-SP-II.; |
| Subunit: | |
Monomer. {ECO:0000250}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Similarity: | |
Belongs to the peptidase S1 family. Snake venom subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}. |
Annotations taken from UniProtKB at the EBI.