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UniProt functional annotation for O07347 | ||
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| UniProt code: O07347. |
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| Organism: | |
Thermus aquaticus. |
| Taxonomy: | |
Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus. |
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| Function: | |
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. {ECO:0000255|HAMAP-Rule:MF_00306}. |
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| Subunit: | |
Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. {ECO:0000255|HAMAP- Rule:MF_00306}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00306}. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_00306}. |
| Domain: | |
Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC. {ECO:0000255|HAMAP-Rule:MF_00306, ECO:0000269|PubMed:10426959, ECO:0000269|PubMed:14501130, ECO:0000269|PubMed:9002524}. |
| Similarity: | |
Belongs to the GTP-binding SRP family. SRP54 subfamily. {ECO:0000255|HAMAP-Rule:MF_00306}. |
Annotations taken from UniProtKB at the EBI.