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PDBsum entry 1oiq
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Imidazo[1,2-A]pyridines: a potent and selective class of cyclin-Dependent kinase inhibitors identified through structure-Based hybridisation.
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Authors
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M.Anderson,
J.F.Beattie,
G.A.Breault,
J.Breed,
K.F.Byth,
J.D.Culshaw,
R.P.Ellston,
S.Green,
C.A.Minshull,
R.A.Norman,
R.A.Pauptit,
J.Stanway,
A.P.Thomas,
P.J.Jewsbury.
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Ref.
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Bioorg Med Chem Lett, 2003,
13,
3021-3026.
[DOI no: ]
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PubMed id
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Abstract
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High-throughput screening identified the imidazo[1,2-a]pyridine and
bisanilinopyrimidine series as inhibitors of the cyclin-dependent kinase CDK4.
Comparison of their experimentally-determined binding modes and emerging
structure-activity trends led to the development of potent and selective
imidazo[1,2-a]pyridine inhibitors for CDK4 and in particular CDK2.
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Secondary reference #1
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Title
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High-Resolution crystal structures of human cyclin-Dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.
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Authors
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U.Schulze-Gahmen,
H.L.De bondt,
S.H.Kim.
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Ref.
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J Med Chem, 1996,
39,
4540-4546.
[DOI no: ]
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PubMed id
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