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UniProt functional annotation for P43772 | ||
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| UniProt code: P43772. |
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| Organism: | |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus. |
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| Function: | |
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. |
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| Catalytic activity: | |
Reaction=ATP-dependent cleavage of peptide bonds with broad specificity.; EC=3.4.25.2; Evidence={ECO:0000255|HAMAP- Rule:MF_00248}; |
| Activity regulation: | |
Allosterically activated by HslU binding. {ECO:0000255|HAMAP-Rule:MF_00248, ECO:0000269|PubMed:12054822}. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=2.3 uM for Arc-H(6)-SulA(CT) {ECO:0000269|PubMed:15037245}; Note=Arc-H(6)-SulA(CT) is a construct consisting of the Arc repressor protein fused to 6 His residues and the 11 carboxy terminal residues of SulA.; |
| Subunit: | |
A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP. {ECO:0000255|HAMAP- Rule:MF_00248, ECO:0000269|PubMed:11106733, ECO:0000269|PubMed:11717526, ECO:0000269|PubMed:12054822, ECO:0000269|PubMed:12823960}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00248}. |
| Similarity: | |
Belongs to the peptidase T1B family. HslV subfamily. {ECO:0000255|HAMAP-Rule:MF_00248}. |
Annotations taken from UniProtKB at the EBI.