UniProt functional annotation for Q24368



	UniProt functional annotation for Q24368

UniProt code: Q24368.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex) (PubMed:10856248, PubMed:11447119). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis (PubMed:12502740, PubMed:16264191, PubMed:8521501, PubMed:8521502). {ECO:0000269|PubMed:10856248, ECO:0000269|PubMed:11447119, ECO:0000269|PubMed:12502740, ECO:0000269|PubMed:16264191, ECO:0000269|PubMed:8521501, ECO:0000269|PubMed:8521502}.

Subunit: Component of the NURF complex composed of Caf1-55, E(bx), Nurf-38 and Iswi (PubMed:8521502). Component of the chromatin accessibility complex (CHRAC), composed of Chrac-14, Chrac-16, Acf and Iswi (PubMed:10856248, PubMed:11447119). Interacts directly with Chrac- 14 and this interaction is further stabilized by associated Chrac-16 (PubMed:10856248). {ECO:0000269|PubMed:10856248, ECO:0000269|PubMed:11447119, ECO:0000269|PubMed:8521502}.

Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:8521502}.

Developmental stage: Present throughout embryonic, larval and pupal development and in female adults. Present at low levels in adult males (at protein level). {ECO:0000269|PubMed:8521502}.

Similarity: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex) (PubMed:10856248, PubMed:11447119). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis (PubMed:12502740, PubMed:16264191, PubMed:8521501, PubMed:8521502). {ECO:0000269\|PubMed:10856248, ECO:0000269\|PubMed:11447119, ECO:0000269\|PubMed:12502740, ECO:0000269\|PubMed:16264191, ECO:0000269\|PubMed:8521501, ECO:0000269\|PubMed:8521502}.


Subunit:		Component of the NURF complex composed of Caf1-55, E(bx), Nurf-38 and Iswi (PubMed:8521502). Component of the chromatin accessibility complex (CHRAC), composed of Chrac-14, Chrac-16, Acf and Iswi (PubMed:10856248, PubMed:11447119). Interacts directly with Chrac- 14 and this interaction is further stabilized by associated Chrac-16 (PubMed:10856248). {ECO:0000269\|PubMed:10856248, ECO:0000269\|PubMed:11447119, ECO:0000269\|PubMed:8521502}.
Subcellular location:		Nucleus {ECO:0000255\|PROSITE-ProRule:PRU00624, ECO:0000269\|PubMed:8521502}.
Developmental stage:		Present throughout embryonic, larval and pupal development and in female adults. Present at low levels in adult males (at protein level). {ECO:0000269\|PubMed:8521502}.
Similarity:		Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. {ECO:0000305}.