UniProt functional annotation for Q60787



	UniProt functional annotation for Q60787

UniProt code: Q60787.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Involved in T-cell antigen receptor mediated signaling. {ECO:0000269|PubMed:10660534}.

Subunit: Interacts with SHB. Interacts with PRAM1 (By similarity). Interacts with SLA (PubMed:10662792). Interacts with GRB2 (PubMed:7706237). Interacts with CBLB (PubMed:10646608). Interacts (via SH2 domain) with CD6 (via tyrosine phosphorylated C-terminus) (PubMed:16914752, PubMed:24584089). Interacts with FYB1 and the phosphorylated form of FYB2 (By similarity). {ECO:0000250|UniProtKB:Q13094, ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10662792, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:24584089, ECO:0000269|PubMed:7706237}.

Subcellular location: Cytoplasm {ECO:0000305}.

Tissue specificity: Highly expressed in spleen, thymus, and peripheral blood leukocytes.

Domain: The SH2 domain mediates interaction with SHB. {ECO:0000250}.

Ptm: Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components (By similarity). {ECO:0000250}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Involved in T-cell antigen receptor mediated signaling. {ECO:0000269\|PubMed:10660534}.


Subunit:		Interacts with SHB. Interacts with PRAM1 (By similarity). Interacts with SLA (PubMed:10662792). Interacts with GRB2 (PubMed:7706237). Interacts with CBLB (PubMed:10646608). Interacts (via SH2 domain) with CD6 (via tyrosine phosphorylated C-terminus) (PubMed:16914752, PubMed:24584089). Interacts with FYB1 and the phosphorylated form of FYB2 (By similarity). {ECO:0000250\|UniProtKB:Q13094, ECO:0000269\|PubMed:10646608, ECO:0000269\|PubMed:10662792, ECO:0000269\|PubMed:16914752, ECO:0000269\|PubMed:24584089, ECO:0000269\|PubMed:7706237}.
Subcellular location:		Cytoplasm {ECO:0000305}.
Tissue specificity:		Highly expressed in spleen, thymus, and peripheral blood leukocytes.
Domain:		The SH2 domain mediates interaction with SHB. {ECO:0000250}.
Ptm:		Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components (By similarity). {ECO:0000250}.