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UniProt functional annotation for P70348 | ||
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| UniProt code: P70348. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Transcription factor that is necessary for placental development (PubMed:8962155). Involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (By similarity). {ECO:0000250|UniProtKB:Q9NP62, ECO:0000269|PubMed:8962155}. |
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| Subcellular location: | |
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00245}. |
| Tissue specificity: | |
Placenta specific. {ECO:0000269|PubMed:8814290}. |
| Ptm: | |
Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro). {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.