UniProt functional annotation for P97318



	UniProt functional annotation for P97318

UniProt code: P97318.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity. {ECO:0000269|PubMed:9009273}.

Subunit: Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain) (PubMed:15062102). Interacts with SIAH1, LRP8 and VLDLR (PubMed:12646221, PubMed:12737822). Interacts with LRP1 (By similarity). Interacts with APLP1 (via NPXY motif) (PubMed:12826668). Interacts with DAB2IP (By similarity). {ECO:0000250|UniProtKB:O75553, ECO:0000250|UniProtKB:Q8CJH2, ECO:0000269|PubMed:12646221, ECO:0000269|PubMed:12737822, ECO:0000269|PubMed:12826668, ECO:0000269|PubMed:15062102, ECO:0000269|PubMed:9009273}.

Tissue specificity: Expressed mainly in brain. {ECO:0000269|PubMed:9009273}.

Domain: The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.

Ptm: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (PubMed:11279201). Also found phosphorylated on Tyr- 232 upon reelin induction (PubMed:15062102). Also phosphorylated on Ser-524 independently of reelin signaling. {ECO:0000269|PubMed:10959835, ECO:0000269|PubMed:11279201, ECO:0000269|PubMed:12077184, ECO:0000269|PubMed:15062102}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Adapter molecule functioning in neural development. May regulate SIAH1 activity. {ECO:0000269\|PubMed:9009273}.


Subunit:		Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain) (PubMed:15062102). Interacts with SIAH1, LRP8 and VLDLR (PubMed:12646221, PubMed:12737822). Interacts with LRP1 (By similarity). Interacts with APLP1 (via NPXY motif) (PubMed:12826668). Interacts with DAB2IP (By similarity). {ECO:0000250\|UniProtKB:O75553, ECO:0000250\|UniProtKB:Q8CJH2, ECO:0000269\|PubMed:12646221, ECO:0000269\|PubMed:12737822, ECO:0000269\|PubMed:12826668, ECO:0000269\|PubMed:15062102, ECO:0000269\|PubMed:9009273}.
Tissue specificity:		Expressed mainly in brain. {ECO:0000269\|PubMed:9009273}.
Domain:		The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.
Ptm:		Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (PubMed:11279201). Also found phosphorylated on Tyr- 232 upon reelin induction (PubMed:15062102). Also phosphorylated on Ser-524 independently of reelin signaling. {ECO:0000269\|PubMed:10959835, ECO:0000269\|PubMed:11279201, ECO:0000269\|PubMed:12077184, ECO:0000269\|PubMed:15062102}.