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PDBsum entry 1ntp
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Hydrolase (serine proteinase) PDB id
1ntp

 

 

 

 

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Contents
Protein chain
223 a.a. *
Ligands
ISP
* Residue conservation analysis
PDB id:
1ntp
Name: Hydrolase (serine proteinase)
Title: Use of the neutron diffraction h/d exchange technique to determine the conformational dynamics of trypsin
Structure: Beta-trypsin. Chain: a. Engineered: yes
Source: Bos taurus. Cattle. Organism_taxid: 9913
Authors: A.A.Kossiakoff
Key ref: A.A.Kossiakoff (1984). Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin. Basic Life Sci, 27, 281-304. PubMed id: 6712567
Date:
16-Sep-87     Release date:   16-Jan-88    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00760  (TRY1_BOVIN) -  Serine protease 1 from Bos taurus
Seq:
Struc: 		246 a.a.
223 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.4.21.4  - trypsin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

 

 
Basic Life Sci 27:281-304 (1984)
PubMed id: 6712567  
 
 
Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin.
A.A.Kossiakoff.
 
  ABSTRACT  
 

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
19271773 T.M.Epstein, U.Samanta, S.D.Kirby, D.M.Cerasoli, and B.J.Bahnson (2009).
Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin.
  Biochemistry, 48, 3425-3435.
PDB codes: 3dt6 3dt8 3dt9
19394314 U.Samanta, S.D.Kirby, P.Srinivasan, D.M.Cerasoli, and B.J.Bahnson (2009).
Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes.
  Biochem Pharmacol, 78, 420-429.
PDB codes: 3f96 3f97 3f98 3f9c
  19255494 W.R.Novak, A.G.Moulin, M.P.Blakeley, I.Schlichting, G.A.Petsko, and D.Ringe (2009).
A preliminary neutron diffraction study of gamma-chymotrypsin.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 317-320.  
18186490 T.J.Kamerzell, and C.R.Middaugh (2008).
The complex inter-relationships between protein flexibility and stability.
  J Pharm Sci, 97, 3494-3517.  
10713988 M.Glick, and A.Goldblum (2000).
A novel energy-based stochastic method for positioning polar protons in protein structures from X-rays.
  Proteins, 38, 273-287.  
8302861 E.Pizzi, A.Tramontano, L.Tomei, N.La Monica, C.Failla, M.Sardana, T.Wood, and R.De Francesco (1994).
Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.
  Proc Natl Acad Sci U S A, 91, 888-892.  
1372979 M.B.Bass, D.F.Hopkins, W.A.Jaquysh, and R.L.Ornstein (1992).
A method for determining the positions of polar hydrogens added to a protein structure that maximizes protein hydrogen bonding.
  Proteins, 12, 266-277.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

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