UniProt functional annotation for P18708



	UniProt functional annotation for P18708

UniProt code: P18708.

Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus.

Function: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling. {ECO:0000269|PubMed:2542798}.

Catalytic activity: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6;

Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305|PubMed:9731775}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000305|PubMed:9731775};

Subunit: Homohexamer. Interacts with GABARAP and GABARAPL2 (By similarity). Interacts with GRIA2 (By similarity). Interacts with PLK2, leading to disrupt the interaction with GRIA2 (By similarity). Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 (By similarity). {ECO:0000250}.

Subcellular location: Cytoplasm.

Ptm: Phosphorylation at Ser-569 interferes with homohexamerization. {ECO:0000250}.

Similarity: Belongs to the AAA ATPase family. {ECO:0000305}.

Sequence caution: Sequence=CAA33678.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus.



Function:		Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling. {ECO:0000269\|PubMed:2542798}.


Catalytic activity:		Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6;
Cofactor:		Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305\|PubMed:9731775}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000305\|PubMed:9731775};
Subunit:		Homohexamer. Interacts with GABARAP and GABARAPL2 (By similarity). Interacts with GRIA2 (By similarity). Interacts with PLK2, leading to disrupt the interaction with GRIA2 (By similarity). Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 (By similarity). {ECO:0000250}.
Subcellular location:		Cytoplasm.
Ptm:		Phosphorylation at Ser-569 interferes with homohexamerization. {ECO:0000250}.
Similarity:		Belongs to the AAA ATPase family. {ECO:0000305}.
Sequence caution:		Sequence=CAA33678.1; Type=Erroneous initiation; Evidence={ECO:0000305};