PDBsum entry 1nf7

Oxidoreductase

PDB id: 1nf7

Contents

Protein chains

454 a.a. *

Ligands

RVP ×2

MYD ×2

UNL ×11

Metals

__K ×2

Waters ×93

* Residue conservation analysis

PDB id:

1nf7

Name:

Oxidoreductase

Title:

Ternary complex of the human type ii inosine monophosphate dedhydrogenase with ribavirin monophosphate and c2-mycophenolic adenine dinucleotide

Structure:

Inosine-5'-monophosphate dehydrogenase 2. Chain: a, b. Synonym: imp dehydrogenase 2, impdh-ii, impd 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: impdh2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Biol. unit:

Tetramer (from PDB file)

Resolution:

2.65Å R-factor: 0.238 R-free: 0.277

Authors:

D.Risal,M.D.Strickler,B.M.Goldstein

Key ref:

D.Risal et al. Crystal structure of human inosine monophosphate dehydrogenase type ii complexed with the mpa/NAD analog c2-Mad. To be published, .

Date:

13-Dec-02 Release date: 27-Jan-04

Protein chains

P12268  (IMDH2_HUMAN) -  Inosine-5'-monophosphate dehydrogenase 2 from Homo sapiens

Seq: 514 a.a.

Struc: 454 a.a.

Enzyme reactions

• Enzyme class: E.C.1.1.1.205 - Imp dehydrogenase.
• Pathway: AMP and GMP Biosynthesis
• Reaction: IMP + NAD⁺ + H2O = XMP + NADH + H⁺

IMP (Bound ligand (Het Group name = MYD) matches with 46.67% similarity) + NAD(+) (Bound ligand (Het Group name = RVP) matches with 41.30% similarity) + H2O = XMP + NADH + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site