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UniProt functional annotation for Q9JK83 | ||
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| UniProt code: Q9JK83. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. {ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:11839275}. |
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| Subunit: | |
Interacts with PARD3. Interacts with GTP-bound forms of CDC42, RHOQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2 (By similarity). Interacts with PALS1. {ECO:0000250, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:12545177, ECO:0000269|PubMed:12606577, ECO:0000269|PubMed:15140881}. |
| Subcellular location: | |
Cytoplasm. Cell membrane. Cell junction, tight junction. Note=Colocalizes with active form of CDC42 or RAC1 at membrane ruffles. Also localizes to tight junctions. |
| Tissue specificity: | |
Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. |
| Domain: | |
The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. {ECO:0000269|PubMed:12545177}. |
| Domain: | |
The PDZ domain mediates the interaction with PALS1. {ECO:0000269|PubMed:12545177}. |
| Similarity: | |
Belongs to the PAR6 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.