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UniProt functional annotation for P12676 | ||
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| UniProt code: P12676. |
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| Organism: | |
Streptomyces sp. (strain SA-COO). |
| Taxonomy: | |
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces. |
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| Function: | |
Bifunctional enzyme that catalyzes the oxidation of the 3- beta-hydroxy group of cholesterol and the isomerization of the double bond of the resulting product. |
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| Catalytic activity: | |
Reaction=cholesterol + O2 = cholest-5-en-3-one + H2O2; Xref=Rhea:RHEA:32183, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:16240, ChEBI:CHEBI:63906; EC=1.1.3.6; Evidence={ECO:0000269|PubMed:10194345}; |
| Catalytic activity: | |
Reaction=a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid; Xref=Rhea:RHEA:14709, ChEBI:CHEBI:47907, ChEBI:CHEBI:47909; EC=5.3.3.1; Evidence={ECO:0000269|PubMed:10194345}; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; |
| Pathway: | |
Steroid metabolism; cholesterol metabolism. |
| Subunit: | |
Monomer. |
| Subcellular location: | |
Secreted. |
| Ptm: | |
Predicted to be exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. |
| Similarity: | |
Belongs to the GMC oxidoreductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.