UniProt functional annotation for P45446



	UniProt functional annotation for P45446

UniProt code: P45446.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity. {ECO:0000269|PubMed:12958591, ECO:0000269|PubMed:8816759}.

Function: [Isoform 1]: Critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity). {ECO:0000250|UniProtKB:Q8R1B8}.

Subunit: Monomer. Interacts with CRX. {ECO:0000269|PubMed:11689423, ECO:0000269|PubMed:12958591, ECO:0000269|PubMed:8816759}.

Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q92753}.

Tissue specificity: Isoform 2 expressed with circadian rhythm in eye and pineal gland. Isoform 1 expressed in retina cortex, thalamus, and hypothalamus. {ECO:0000269|PubMed:9670004, ECO:0000269|PubMed:9729429}.

Induction: [Isoform 2]: Oscillates diurnally in eye and pineal gland, with highest levels shortly after midnight. {ECO:0000269|PubMed:9729429}.

Domain: AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity (PubMed:8816759 and PubMed:11689423). {ECO:0000269|PubMed:11689423, ECO:0000269|PubMed:8816759}.

Miscellaneous: [Isoform 2]: Shows a 4-fold higher transcriptional activation of an optimal promoter compared to isoform 1.

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAA42095.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity. {ECO:0000269\|PubMed:12958591, ECO:0000269\|PubMed:8816759}.



Function:		[Isoform 1]: Critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity). {ECO:0000250\|UniProtKB:Q8R1B8}.


Subunit:		Monomer. Interacts with CRX. {ECO:0000269\|PubMed:11689423, ECO:0000269\|PubMed:12958591, ECO:0000269\|PubMed:8816759}.
Subcellular location:		Nucleus, nucleoplasm {ECO:0000250\|UniProtKB:Q92753}.
Tissue specificity:		Isoform 2 expressed with circadian rhythm in eye and pineal gland. Isoform 1 expressed in retina cortex, thalamus, and hypothalamus. {ECO:0000269\|PubMed:9670004, ECO:0000269\|PubMed:9729429}.
Induction:		[Isoform 2]: Oscillates diurnally in eye and pineal gland, with highest levels shortly after midnight. {ECO:0000269\|PubMed:9729429}.
Domain:		AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity (PubMed:8816759 and PubMed:11689423). {ECO:0000269\|PubMed:11689423, ECO:0000269\|PubMed:8816759}.
Miscellaneous:		[Isoform 2]: Shows a 4-fold higher transcriptional activation of an optimal promoter compared to isoform 1.
Similarity:		Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAA42095.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};