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UniProt functional annotation for P42773 | ||
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| UniProt code: P42773. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
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| Subunit: | |
Heterodimer of p18 with CDK6. |
| Tissue specificity: | |
Highest levels found in skeletal muscle. Also found in pancreas and heart. |
| Similarity: | |
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.