PDBsum entry 1mv5

Transport protein

PDB id: 1mv5

Contents

Protein chains

242 a.a. *

Ligands

ATP ×2

ADP ×2

Metals

_MG ×2

Waters ×78

* Residue conservation analysis

PDB id:

1mv5

Name:

Transport protein

Title:

Crystal structure of lmra atp-binding domain

Structure:

Multidrug resistance abc transporter atp-binding and permease protein. Chain: a, b, c, d. Fragment: atp-binding domain. Synonym: lmra. Engineered: yes

Source:

Lactococcus lactis. Organism_taxid: 1358. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

3.10Å R-factor: 0.251 R-free: 0.283

Authors:

Y.Yuan,H.Chen,D.Patel

Key ref:

Y.Yuan et al. Crystal structure of lmra ATP-Binding domain reveals the two-Site alternating mechanism at molecular level. To be published, .

Date:

24-Sep-02 Release date: 02-Dec-03

Protein chains

Q9CHL8  (LMRA_LACLA) -  Multidrug resistance ABC transporter ATP-binding and permease protein from Lactococcus lactis subsp. lactis (strain IL1403)

Seq: 590 a.a.

Struc: 242 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.7.6.2.2 - ABC-type xenobiotic transporter.
• Reaction: ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2

ATP (Bound ligand (Het Group name = ATP) corresponds exactly) + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2

Molecule diagrams generated from .mol files obtained from the KEGG ftp site