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PDBsum entry 1muq
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Sugar binding protein
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PDB id
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1muq
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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X-Ray crystal structure of a galactose-Specific c-Type lectin possessing a novel decameric quaternary structure.
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Authors
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J.R.Walker,
B.Nagar,
N.M.Young,
T.Hirama,
J.M.Rini.
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Ref.
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Biochemistry, 2004,
43,
3783-3792.
[DOI no: ]
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PubMed id
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Abstract
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Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake
(Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The X-ray
crystal structure of RSL, in complex with lactose and thiodigalactoside, at 2.2
and 2.3 A resolution, respectively, reveals a decameric protein composed of two
5-fold symmetric pentamers arranged in a staggered, back-to-back orientation.
Each monomer corresponds to a single canonical C-type lectin carbohydrate
recognition domain devoid of accessory domains and is disulfide-bonded to a
monomer in the other pentamer. The structure is the first example of that of a
carbohydrate complex of a vertebrate galactose-specific C-type lectin. The 10
carbohydrate-binding sites, located on the rim of the decamer, suggest a role
for multivalent interactions and a mechanism for RSL's ability to promote
receptor cross-linking and cell aggregation.
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Secondary reference #1
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Title
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Isolation and characterization of three ca2+-Dependent beta-Galactoside-Specific lectins from snake venoms.
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Authors
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T.K.Gartner,
M.L.Ogilvie.
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Ref.
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Biochem J, 1984,
224,
301-307.
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PubMed id
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Secondary reference #2
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Title
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Complete primary structure of a galactose-Specific lectin from the venom of the rattlesnake crotalus atrox. Homologies with ca2(+)-Dependent-Type lectins.
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Authors
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J.Hirabayashi,
T.Kusunoki,
K.Kasai.
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Ref.
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J Biol Chem, 1991,
266,
2320-2326.
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PubMed id
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