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UniProt functional annotation for Q62261 | ||
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| UniProt code: Q62261. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
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| Subunit: | |
Interacts with ANK2 (PubMed:15262991). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Interacts with CAMSAP1 (By similarity). {ECO:0000250|UniProtKB:P85986, ECO:0000250|UniProtKB:Q01082, ECO:0000269|PubMed:12522145, ECO:0000269|PubMed:15262991}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton {ECO:0000305}. Endomembrane system {ECO:0000269|PubMed:15262991}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:15262991}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. {ECO:0000269|PubMed:15262991}. |
| Subcellular location: | |
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:9927192}. Cell membrane {ECO:0000269|PubMed:9927192}; Peripheral membrane protein; Cytoplasmic side. |
| Tissue specificity: | |
Isoform 2 is present in brain, heart, kidney and liver (at protein level). {ECO:0000269|PubMed:15262991, ECO:0000269|PubMed:9927192}. |
| Developmental stage: | |
Isoform 2 is expressed in brain, heart and liver throughout embryonic development. Isoform 1 is mainly expressed in neonatal developing ventricular cardiomyocytes. {ECO:0000269|PubMed:9927192}. |
| Similarity: | |
Belongs to the spectrin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.