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UniProt functional annotation for P54939 | ||
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| UniProt code: P54939. |
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| Organism: | |
Gallus gallus (Chicken). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus. |
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| Function: | |
Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. |
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| Subunit: | |
Interacts with PIP5K1C and NRAP (By similarity). Binds with high affinity to vinculin VCL and with low affinity to integrins (PubMed:14702644, PubMed:12535520, PubMed:8937989, PubMed:20610383). Interacts with APBB1IP; this inhibits VCL binding (By similarity). Interacts with F-actin (PubMed:8937989). Interacts with LAYN (PubMed:9786953). Interacts with THSD1. {ECO:0000250|UniProtKB:P26039, ECO:0000250|UniProtKB:Q9Y490, ECO:0000269|PubMed:12535520, ECO:0000269|PubMed:14702644, ECO:0000269|PubMed:20610383, ECO:0000269|PubMed:8937989, ECO:0000269|PubMed:9786953}. |
| Subcellular location: | |
Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. |
| Ptm: | |
Phosphorylated. {ECO:0000250|UniProtKB:P26039, ECO:0000250|UniProtKB:Q9Y490}. |
Annotations taken from UniProtKB at the EBI.