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Contents |
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277 a.a.
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99 a.a.
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201 a.a.
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241 a.a.
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* Residue conservation analysis
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PDB id:
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Immune system
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Title:
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The crystal structure of lc13 tcr in complex with hlab8-ebv peptide complex
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Structure:
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Mhc heavy chain. Chain: a. Fragment: extracellular domain. Synonym: hla class i histocompatibility antigen, b-8 b 0801 Alpha chain. Engineered: yes. Beta 2 microglobulin. Chain: b. Engineered: yes.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: epstein barr virus peptide was chemically synthesized.. Expression_system_taxid: 562
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Biol. unit:
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Pentamer (from
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Resolution:
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2.50Å
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R-factor:
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0.226
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R-free:
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0.288
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Authors:
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L.Kjer-Nielsen,C.S.Clements,A.W.Purcell,A.G.Brooks,J.C.Whisstock, S.R.Burrows,J.Mccluskey,J.Rossjohn
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Key ref:
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L.Kjer-Nielsen
et al.
(2003).
A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity.
Immunity,
18,
53-64.
PubMed id:
DOI:
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Date:
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21-Aug-02
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Release date:
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04-Feb-03
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PROCHECK
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Headers
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References
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P01889
(1B07_HUMAN) -
HLA class I histocompatibility antigen, B alpha chain from Homo sapiens
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Seq:
Struc:
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362 a.a.
277 a.a.*
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P61769
(B2MG_HUMAN) -
Beta-2-microglobulin from Homo sapiens
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Seq:
Struc:
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119 a.a.
99 a.a.
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DOI no:
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Immunity
18:53-64
(2003)
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PubMed id:
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A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity.
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L.Kjer-Nielsen,
C.S.Clements,
A.W.Purcell,
A.G.Brooks,
J.C.Whisstock,
S.R.Burrows,
J.McCluskey,
J.Rossjohn.
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ABSTRACT
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We have examined the basis for immunodominant or "public" TCR usage in
an antiviral CTL response. Residues encoded by each of the highly selected
genetic elements of an immunodominant clonotype recognizing Epstein-Barr virus
were critical to the antigen specificity of the receptor. Upon recognizing
antigen, the immunodominant TCR undergoes extensive conformational changes in
the complementarity determining regions (CDRs), including the disruption of the
canonical structures of the germline-encoded CDR1alpha and CDR2alpha loops to
produce an enhanced fit with the HLA-peptide complex. TCR ligation induces
conformational changes in the TCRalpha constant domain thought to form part of
the docking site for CD3epsilon. These findings indicate that TCR
immunodominance is associated with structural properties conferring receptor
specificity and suggest a novel structural link between TCR ligation and
intracellular signaling.
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Selected figure(s)
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Figure 1.
Figure 1. Overview of the LC13 T Cell Receptor Complexed to
HLA-B8/FLRGRAYGL(A) Ribbon representation of the
LC13/HLA-B8/FLRGRAYGL complex. The α chain and β chain of LC13
TCR are shown in light red and blue, respectively. The HLA-B8
heavy chain and the β2-microglobulin domain are shown in light
and darker green, respectively. The bound EBV peptide is in
yellow, with the P7 Tyr residue shown in stick format.(B) A
close-up of the interface, in an orthogonal view to (A), with
the CDR regions color coded CDR1α, red; CDR2α, magenta;
CDR3α, blue; CDR1β, orange; CDR2β, green; and CDR3β, cyan.
Residues from CDR1 and CDR2 participating in polar contacts are
highlighted.(C) Involvement of the publicly encoded regions that
encompass CDR3 at the interface. The CDR3α loop residues and
their corresponding amino acid sequence are color coded with the
Vα backbone in red, N-region in dark blue, and Jα in dark
green; CDR3β loop residues are coded with the Vβ backbone in
orange; DβN-region light blue and Jβ light green. Residues P6
Ala, P7 Tyr, and P8 Gly of the FLRGRAYGL peptide are shown in
yellow. Part of the HLA-B8 α2 helix has been removed to
simplify the illustration. Selected residues from the HLA-B8 α1
and α2 helices are shown in gray.
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Figure 4.
Figure 4. Conformational Change in the Cα Domain that May
Relate to a Conformational Switch for Intracellular Signaling in
T Cells(A) The acidic ectodomain of CD3ε has been proposed to
interact with the exposed electropositive surface of the A, B,
E, and D strands of the Cβ domain shown in light green
(Ghendler et al. 1998; Sun et al. 2001 and Wang et al. 1998).
This cavity is bordered by the F-G loop of the Cβ domain.
Conformational changes between unliganded (cyan) and liganded
(red) states of this region are shown. Positively charged side
chains (K121, K132, K136, K184, R190, and R230) projecting from
Cα and Cβ are thought to further stabilize the docking of
CD3ε into this cavity (Sun et al., 2001). Cα Lys132 swings
toward the cavity upon ligation of LC13 while the whole of the
A-B loop shifts to enlarge the cavity in the liganded
complex.(B) Comparison of A-B loop structure in a number of
different TCRs. Color coding of the A-B loop is as follows:
unliganded LC13, cyan; liganded LC13, red; 2C, blue; A6 weak
agonist, green; and the partially built loop of the B7 TCR,
orange. The N15 A-B loop structure is not shown but resembles
the 2C structure.
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The above figures are
reprinted
by permission from Cell Press:
Immunity
(2003,
18,
53-64)
copyright 2003.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.J.Miles,
D.C.Douek,
and
D.A.Price
(2011).
Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination.
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Immunol Cell Biol,
89,
375-387.
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J.M.Khan,
and
S.Ranganathan
(2011).
Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One.
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PLoS One,
6,
e17194.
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P.A.van der Merwe,
and
O.Dushek
(2011).
Mechanisms for T cell receptor triggering.
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Nat Rev Immunol,
11,
47-55.
|
|
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|
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S.Gras,
L.Kjer-Nielsen,
Z.Chen,
J.Rossjohn,
and
J.McCluskey
(2011).
The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection.
|
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Immunol Cell Biol,
89,
388-395.
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G.I.van Boxel,
S.Holmes,
L.Fugger,
and
E.Y.Jones
(2010).
An alternative conformation of the T-cell receptor alpha constant region.
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J Mol Biol,
400,
828-837.
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PDB code:
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J.D.Ahlers,
and
I.M.Belyakov
(2010).
Lessons learned from natural infection: focusing on the design of protective T cell vaccines for HIV/AIDS.
|
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Trends Immunol,
31,
120-130.
|
|
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|
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J.J.Miles,
A.M.Bulek,
D.K.Cole,
E.Gostick,
A.J.Schauenburg,
G.Dolton,
V.Venturi,
M.P.Davenport,
M.P.Tan,
S.R.Burrows,
L.Wooldridge,
D.A.Price,
P.J.Rizkallah,
and
A.K.Sewell
(2010).
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.
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PLoS Pathog,
6,
e1001198.
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PDB code:
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J.Liu,
P.Wu,
F.Gao,
J.Qi,
A.Kawana-Tachikawa,
J.Xie,
C.J.Vavricka,
A.Iwamoto,
T.Li,
and
G.F.Gao
(2010).
Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein.
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J Virol,
84,
11849-11857.
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PDB code:
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J.Z.Yang,
M.W.Li,
J.G.Wang,
H.F.Lu,
X.S.Yao,
J.Q.He,
and
L.J.Li
(2010).
Rapid detection of clonal expansion of T-cell receptor-beta gene in patients with HBV using the real-time PCR with DNA melting curve analysis.
|
| |
Hepatol Res,
40,
407-414.
|
|
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|
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K.Kedzierska,
S.A.Valkenburg,
C.Guillonneau,
F.X.Hubert,
T.Cukalac,
J.M.Curtis,
J.Stambas,
H.S.Scott,
L.Kedzierski,
V.Venturi,
and
M.P.Davenport
(2010).
Diversity and clonotypic composition of influenza-specific CD8+ TCR repertoires remain unaltered in the absence of Aire.
|
| |
Eur J Immunol,
40,
849-858.
|
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|
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|
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L.Wooldridge,
M.Clement,
A.Lissina,
E.S.Edwards,
K.Ladell,
J.Ekeruche,
R.E.Hewitt,
B.Laugel,
E.Gostick,
D.K.Cole,
R.Debets,
C.Berrevoets,
J.J.Miles,
S.R.Burrows,
D.A.Price,
and
A.K.Sewell
(2010).
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
|
| |
J Immunol,
184,
3357-3366.
|
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|
|
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|
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M.Salio,
J.D.Silk,
and
V.Cerundolo
(2010).
Recent advances in processing and presentation of CD1 bound lipid antigens.
|
| |
Curr Opin Immunol,
22,
81-88.
|
|
|
|
|
|
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N.L.La Gruta,
W.T.Rothwell,
T.Cukalac,
N.G.Swan,
S.A.Valkenburg,
K.Kedzierska,
P.G.Thomas,
P.C.Doherty,
and
S.J.Turner
(2010).
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion.
|
| |
J Clin Invest,
120,
1885-1894.
|
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|
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P.Miqueu,
N.Degauque,
M.Guillet,
M.Giral,
C.Ruiz,
A.Pallier,
C.Braudeau,
G.Roussey-Kesler,
J.Ashton-Chess,
J.C.Doré,
E.Thervet,
C.Legendre,
M.P.Hernandez-Fuentes,
A.N.Warrens,
M.Goldman,
H.D.Volk,
U.Janssen,
K.J.Wood,
R.I.Lechler,
D.Bertrand,
V.Sébille,
J.P.Soulillou,
and
S.Brouard
(2010).
Analysis of the peripheral T-cell repertoire in kidney transplant patients.
|
| |
Eur J Immunol,
40,
3280-3290.
|
|
|
|
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|
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S.A.Valkenburg,
E.B.Day,
N.G.Swan,
H.A.Croom,
F.R.Carbone,
P.C.Doherty,
S.J.Turner,
and
K.Kedzierska
(2010).
Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8+ T cells.
|
| |
Eur J Immunol,
40,
2470-2481.
|
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|
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S.R.Burrows,
Z.Chen,
J.K.Archbold,
F.E.Tynan,
T.Beddoe,
L.Kjer-Nielsen,
J.J.Miles,
R.Khanna,
D.J.Moss,
Y.C.Liu,
S.Gras,
L.Kostenko,
R.M.Brennan,
C.S.Clements,
A.G.Brooks,
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
(2010).
Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.
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Proc Natl Acad Sci U S A,
107,
10608-10613.
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PDB codes:
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S.S.Pang,
R.Berry,
Z.Chen,
L.Kjer-Nielsen,
M.A.Perugini,
G.F.King,
C.Wang,
S.H.Chew,
N.L.La Gruta,
N.K.Williams,
T.Beddoe,
T.Tiganis,
N.P.Cowieson,
D.I.Godfrey,
A.W.Purcell,
M.C.Wilce,
J.McCluskey,
and
J.Rossjohn
(2010).
The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.
|
| |
Nature,
467,
844-848.
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PDB code:
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B.Knapp,
U.Omasits,
S.Frantal,
and
W.Schreiner
(2009).
A critical cross-validation of high throughput structural binding prediction methods for pMHC.
|
| |
J Comput Aided Mol Des,
23,
301-307.
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|
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D.G.Pellicci,
O.Patel,
L.Kjer-Nielsen,
S.S.Pang,
L.C.Sullivan,
K.Kyparissoudis,
A.G.Brooks,
H.H.Reid,
S.Gras,
I.S.Lucet,
R.Koh,
M.J.Smyth,
T.Mallevaey,
J.L.Matsuda,
L.Gapin,
J.McCluskey,
D.I.Godfrey,
and
J.Rossjohn
(2009).
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors.
|
| |
Immunity,
31,
47-59.
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PDB codes:
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D.K.Cole,
F.Yuan,
P.J.Rizkallah,
J.J.Miles,
E.Gostick,
D.A.Price,
G.F.Gao,
B.K.Jakobsen,
and
A.K.Sewell
(2009).
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
|
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J Biol Chem,
284,
27281-27289.
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PDB code:
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J.K.Archbold,
W.A.Macdonald,
S.Gras,
L.K.Ely,
J.J.Miles,
M.J.Bell,
R.M.Brennan,
T.Beddoe,
M.C.Wilce,
C.S.Clements,
A.W.Purcell,
J.McCluskey,
S.R.Burrows,
and
J.Rossjohn
(2009).
Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition.
|
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J Exp Med,
206,
209-219.
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PDB codes:
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K.Rubtsova,
J.P.Scott-Browne,
F.Crawford,
S.Dai,
P.Marrack,
and
J.W.Kappler
(2009).
Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.
|
| |
Proc Natl Acad Sci U S A,
106,
7951-7956.
|
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P.Kumar,
A.Vahedi-Faridi,
W.Saenger,
A.Ziegler,
and
B.Uchanska-Ziegler
(2009).
Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity.
|
| |
Protein Sci,
18,
37-49.
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PDB code:
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S.A.Richman,
D.H.Aggen,
M.L.Dossett,
D.L.Donermeyer,
P.M.Allen,
P.D.Greenberg,
and
D.M.Kranz
(2009).
Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments.
|
| |
Mol Immunol,
46,
902-916.
|
|
|
|
|
|
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T.Beddoe,
Z.Chen,
C.S.Clements,
L.K.Ely,
S.R.Bushell,
J.P.Vivian,
L.Kjer-Nielsen,
S.S.Pang,
M.A.Dunstone,
Y.C.Liu,
W.A.Macdonald,
M.A.Perugini,
M.C.Wilce,
S.R.Burrows,
A.W.Purcell,
T.Tiganis,
S.P.Bottomley,
J.McCluskey,
and
J.Rossjohn
(2009).
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
|
| |
Immunity,
30,
777-788.
|
|
|
|
|
|
|
W.A.Macdonald,
Z.Chen,
S.Gras,
J.K.Archbold,
F.E.Tynan,
C.S.Clements,
M.Bharadwaj,
L.Kjer-Nielsen,
P.M.Saunders,
M.C.Wilce,
F.Crawford,
B.Stadinsky,
D.Jackson,
A.G.Brooks,
A.W.Purcell,
J.W.Kappler,
S.R.Burrows,
J.Rossjohn,
and
J.McCluskey
(2009).
T cell allorecognition via molecular mimicry.
|
| |
Immunity,
31,
897-908.
|
|
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PDB codes:
|
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|
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|
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Y.Wang,
D.Becker,
T.Vass,
J.White,
P.Marrack,
and
J.W.Kappler
(2009).
A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling.
|
| |
PLoS Biol,
7,
e1000253.
|
|
|
|
|
|
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D.I.Godfrey,
J.Rossjohn,
and
J.McCluskey
(2008).
The fidelity, occasional promiscuity, and versatility of T cell receptor recognition.
|
| |
Immunity,
28,
304-314.
|
|
|
|
|
|
|
J.H.Wang,
R.J.Mallis,
and
E.L.Reinherz
(2008).
Immunodominant-peptide recognition: beta testing TCRalphabeta.
|
| |
Immunity,
28,
139-141.
|
|
|
|
|
|
|
J.Ishizuka,
G.B.Stewart-Jones,
A.van der Merwe,
J.I.Bell,
A.J.McMichael,
and
E.Y.Jones
(2008).
The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.
|
| |
Immunity,
28,
171-182.
|
|
|
PDB codes:
|
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|
|
|
|
|
|
J.K.Archbold,
W.A.Macdonald,
S.R.Burrows,
J.Rossjohn,
and
J.McCluskey
(2008).
T-cell allorecognition: a case of mistaken identity or déjà vu?
|
| |
Trends Immunol,
29,
220-226.
|
|
|
|
|
|
|
K.K.Wynn,
Z.Fulton,
L.Cooper,
S.L.Silins,
S.Gras,
J.K.Archbold,
F.E.Tynan,
J.J.Miles,
J.McCluskey,
S.R.Burrows,
J.Rossjohn,
and
R.Khanna
(2008).
Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection.
|
| |
Blood,
111,
4283-4292.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Kedzierska,
N.L.La Gruta,
J.Stambas,
S.J.Turner,
and
P.C.Doherty
(2008).
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.
|
| |
Mol Immunol,
45,
607-618.
|
|
|
|
|
|
|
K.Kedzierska,
P.G.Thomas,
V.Venturi,
M.P.Davenport,
P.C.Doherty,
S.J.Turner,
and
N.L.La Gruta
(2008).
Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses.
|
| |
J Immunol,
181,
2556-2562.
|
|
|
|
|
|
|
K.M.Armstrong,
K.H.Piepenbrink,
and
B.M.Baker
(2008).
Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.
|
| |
Biochem J,
415,
183-196.
|
|
|
|
|
|
|
L.Crompton,
N.Khan,
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J Immunol,
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PDB codes:
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M.A.Cuendet,
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Protein-protein interaction investigated by steered molecular dynamics: the TCR-pMHC complex.
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Immunity,
28,
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PDB codes:
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S.Gras,
L.Kjer-Nielsen,
S.R.Burrows,
J.McCluskey,
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EMBO J,
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PDB code:
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D.Feng,
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L.K.Ely,
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Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
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Nat Immunol,
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PDB codes:
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E.Duchardt,
A.B.Sigalov,
D.Aivazian,
L.J.Stern,
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Nat Immunol,
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PDB codes:
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J.Rossjohn,
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How a home-grown T cell receptor interacts with a foreign landscape.
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Nat Immunol,
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PDB codes:
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M.Koch,
S.Camp,
T.Collen,
D.Avila,
J.Salomonsen,
H.J.Wallny,
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Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.
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Immunity,
27,
885-899.
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PDB codes:
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M.Krogsgaard,
J.Juang,
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CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.
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Nature,
448,
44-49.
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PDB code:
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P.J.Miller,
Y.Pazy,
B.Conti,
D.Riddle,
E.Appella,
and
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J Mol Biol,
373,
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PDB codes:
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R.Bello,
M.J.Feito,
G.Ojeda,
P.Portolés,
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J Biol Chem,
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Immunity,
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C.Douat-Casassus,
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P.Picard,
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Covalent modification of a melanoma-derived antigenic peptide with a natural quinone methide. Preliminary chemical, molecular modelling and immunological evaluation studies.
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Mol Biosyst,
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C.Rückert,
M.T.Fiorillo,
B.Loll,
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Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype.
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J Biol Chem,
281,
2306-2316.
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PDB code:
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C.S.Clements,
M.A.Dunstone,
W.A.Macdonald,
J.McCluskey,
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Eur J Immunol,
36,
3288-3293.
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PDB code:
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H.L.Hoare,
L.C.Sullivan,
G.Pietra,
C.S.Clements,
E.J.Lee,
L.K.Ely,
T.Beddoe,
M.Falco,
L.Kjer-Nielsen,
H.H.Reid,
J.McCluskey,
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Structural basis for a major histocompatibility complex class Ib-restricted T cell response.
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Nat Immunol,
7,
256-264.
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PDB code:
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J.K.Archbold,
W.A.Macdonald,
J.J.Miles,
R.M.Brennan,
L.Kjer-Nielsen,
J.McCluskey,
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J Biol Chem,
281,
34324-34332.
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PDB code:
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J.W.Yewdell
(2006).
Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses.
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Immunity,
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K.Irvine,
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Expert Rev Clin Immunol,
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A structural perspective on MHC class Ib molecules in adaptive immunity.
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Trends Immunol,
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L.K.Ely,
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A.W.Purcell,
L.Kjer-Nielsen,
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Proc Natl Acad Sci U S A,
103,
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L.K.Selin,
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L.Kostenko,
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N.A.Williamson,
M.J.Smyth,
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H.H.Reid,
M.Bharadwaj,
D.I.Godfrey,
J.Rossjohn,
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A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
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J Exp Med,
203,
661-673.
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PDB codes:
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M.G.Rudolph,
R.L.Stanfield,
and
I.A.Wilson
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How TCRs bind MHCs, peptides, and coreceptors.
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Annu Rev Immunol,
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M.S.Kuhns,
M.M.Davis,
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Deconstructing the form and function of the TCR/CD3 complex.
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P.P.Yachi,
J.Ampudia,
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Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality.
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Immunity,
25,
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R.M.Risueño,
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A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection.
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Proc Natl Acad Sci U S A,
103,
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S.J.Turner,
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Structural determinants of T-cell receptor bias in immunity.
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Nat Rev Immunol,
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S.R.Burrows,
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Have we cut ourselves too short in mapping CTL epitopes?
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Trends Immunol,
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V.Venturi,
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Proc Natl Acad Sci U S A,
103,
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A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex.
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Trends Immunol,
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D.A.Price,
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J Exp Med,
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D.E.Speiser
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Immunological techniques: ex vivo characterization of T cell-mediated immune responses in cancer.
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D.Gil,
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J Exp Med,
201,
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E.F.Houston,
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Analysis of T-cell receptor BV gene sequences in cattle reveals extensive duplication within the BV9 and BV20 subgroups.
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Immunogenetics,
57,
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E.Y.Jones
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Favorite flavors of surfaces.
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Nat Immunol,
6,
365-366.
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PDB codes:
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F.E.Tynan,
D.Elhassen,
A.W.Purcell,
J.M.Burrows,
N.A.Borg,
J.J.Miles,
N.A.Williamson,
K.J.Green,
J.Tellam,
L.Kjer-Nielsen,
J.McCluskey,
J.Rossjohn,
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The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation.
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J Exp Med,
202,
1249-1260.
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PDB codes:
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|
F.E.Tynan,
N.A.Borg,
J.J.Miles,
T.Beddoe,
D.El-Hassen,
S.L.Silins,
W.J.van Zuylen,
A.W.Purcell,
L.Kjer-Nielsen,
J.McCluskey,
S.R.Burrows,
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High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance.
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J Biol Chem,
280,
23900-23909.
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PDB codes:
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|
F.E.Tynan,
S.R.Burrows,
A.M.Buckle,
C.S.Clements,
N.A.Borg,
J.J.Miles,
T.Beddoe,
J.C.Whisstock,
M.C.Wilce,
S.L.Silins,
J.M.Burrows,
L.Kjer-Nielsen,
L.Kostenko,
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
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T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide.
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| |
Nat Immunol,
6,
1114-1122.
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PDB code:
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H.Li,
S.Van Vranken,
Y.Zhao,
Z.Li,
Y.Guo,
L.Eisele,
and
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Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.
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Protein Sci,
14,
3025-3038.
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PDB codes:
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|
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|
J.L.Chen,
G.Stewart-Jones,
G.Bossi,
N.M.Lissin,
L.Wooldridge,
E.M.Choi,
G.Held,
P.R.Dunbar,
R.M.Esnouf,
M.Sami,
J.M.Boulter,
P.Rizkallah,
C.Renner,
A.Sewell,
P.A.van der Merwe,
B.K.Jakobsen,
G.Griffiths,
E.Y.Jones,
and
V.Cerundolo
(2005).
Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
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J Exp Med,
201,
1243-1255.
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PDB codes:
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|
|
|
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|
|
K.Choudhuri,
A.Kearney,
T.R.Bakker,
and
P.A.van der Merwe
(2005).
Immunology: how do T cells recognize antigen?
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Curr Biol,
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M.Krogsgaard,
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How T cells 'see' antigen.
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Nat Immunol,
6,
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M.T.Fiorillo,
C.Rückert,
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W.Saenger,
A.Ziegler,
and
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(2005).
Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes.
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J Biol Chem,
280,
2962-2971.
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PDB codes:
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|
N.A.Borg,
L.K.Ely,
T.Beddoe,
W.A.Macdonald,
H.H.Reid,
C.S.Clements,
A.W.Purcell,
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J.J.Miles,
S.R.Burrows,
J.McCluskey,
and
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(2005).
The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition.
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Nat Immunol,
6,
171-180.
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S.E.Levin,
and
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(2005).
Twisting tails exposed: the evidence for TCR conformational change.
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J Exp Med,
201,
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S.Huang,
S.Gilfillan,
M.Cella,
M.J.Miley,
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L.Lybarger,
D.H.Fremont,
and
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(2005).
Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.
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J Biol Chem,
280,
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S.J.Turner,
K.Kedzierska,
H.Komodromou,
N.L.La Gruta,
M.A.Dunstone,
A.I.Webb,
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W.Xie,
J.McCluskey,
A.W.Purcell,
J.Rossjohn,
and
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(2005).
Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations.
|
| |
Nat Immunol,
6,
382-389.
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PDB codes:
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|
S.Oerke,
H.Höhn,
I.Zehbe,
H.Pilch,
K.H.Schicketanz,
W.E.Hitzler,
C.Neukirch,
K.Freitag,
and
M.J.Maeurer
(2005).
Naturally processed and HLA-B8-presented HPV16 E7 epitope recognized by T cells from patients with cervical cancer.
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| |
Int J Cancer,
114,
766-778.
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W.W.Schamel,
I.Arechaga,
R.M.Risueño,
H.M.van Santen,
P.Cabezas,
C.Risco,
J.M.Valpuesta,
and
B.Alarcón
(2005).
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.
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J Exp Med,
202,
493-503.
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Y.Li,
Y.Huang,
J.Lue,
J.A.Quandt,
R.Martin,
and
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(2005).
Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.
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| |
EMBO J,
24,
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PDB code:
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|
J.Nikolich-Zugich,
M.K.Slifka,
and
I.Messaoudi
(2004).
The many important facets of T-cell repertoire diversity.
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Nat Rev Immunol,
4,
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K.Kedzierska,
S.J.Turner,
and
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(2004).
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope.
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Proc Natl Acad Sci U S A,
101,
4942-4947.
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L.Kjer-Nielsen,
M.A.Dunstone,
L.Kostenko,
L.K.Ely,
T.Beddoe,
N.A.Mifsud,
A.W.Purcell,
A.G.Brooks,
J.McCluskey,
and
J.Rossjohn
(2004).
Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.
|
| |
Proc Natl Acad Sci U S A,
101,
7675-7680.
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|
PDB code:
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|
|
M.A.Brehm,
L.K.Selin,
and
R.M.Welsh
(2004).
CD8 T cell responses to viral infections in sequence.
|
| |
Cell Microbiol,
6,
411-421.
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P.H.Atkinson
(2004).
Glycosylation of prion strains in transmissible spongiform encephalopathies.
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Aust Vet J,
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P.Thor Straten,
D.Schrama,
M.H.Andersen,
and
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(2004).
T-cell clonotypes in cancer.
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J Transl Med,
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S.J.Turner,
K.Kedzierska,
N.L.La Gruta,
R.Webby,
and
P.C.Doherty
(2004).
Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection.
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Semin Immunol,
16,
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T.Dong,
G.Stewart-Jones,
N.Chen,
P.Easterbrook,
X.Xu,
L.Papagno,
V.Appay,
M.Weekes,
C.Conlon,
C.Spina,
S.Little,
G.Screaton,
A.van der Merwe,
D.D.Richman,
A.J.McMichael,
E.Y.Jones,
and
S.L.Rowland-Jones
(2004).
HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor.
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J Exp Med,
200,
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Z.Y.Sun,
S.T.Kim,
I.C.Kim,
A.Fahmy,
E.L.Reinherz,
and
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(2004).
Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.
|
| |
Proc Natl Acad Sci U S A,
101,
16867-16872.
|
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|
PDB code:
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|
|
A.J.Bankovich,
and
K.C.Garcia
(2003).
Not just any T cell receptor will do.
|
| |
Immunity,
18,
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A.Sette,
and
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(2003).
Epitope-based vaccines: an update on epitope identification, vaccine design and delivery.
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D.H.Margulies
(2003).
Molecular interactions: stiff or floppy (or somewhere in between?).
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Immunity,
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D.Housset,
and
B.Malissen
(2003).
What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity?
|
| |
Trends Immunol,
24,
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|
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J.Buslepp,
H.Wang,
W.E.Biddison,
E.Appella,
and
E.J.Collins
(2003).
A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection.
|
| |
Immunity,
19,
595-606.
|
|
|
PDB code:
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|
M.Krogsgaard,
J.B.Huppa,
M.A.Purbhoo,
and
M.M.Davis
(2003).
Linking molecular and cellular events in T-cell activation and synapse formation.
|
| |
Semin Immunol,
15,
307-315.
|
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|
M.Krogsgaard,
N.Prado,
E.J.Adams,
X.L.He,
D.C.Chow,
D.B.Wilson,
K.C.Garcia,
and
M.M.Davis
(2003).
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.
|
| |
Mol Cell,
12,
1367-1378.
|
|
|
PDB codes:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
| |
Links
