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PDBsum entry 1mhc
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Histocompatibility antigen/peptide
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PDB id
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1mhc
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Nonclassical binding of formylated peptide in crystal structure of the mhc class ib molecule h2-M3.
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Authors
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C.R.Wang,
A.R.Castaño,
P.A.Peterson,
C.Slaughter,
K.F.Lindahl,
J.Deisenhofer.
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Ref.
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Cell, 1995,
82,
655-664.
[DOI no: ]
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PubMed id
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Abstract
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H2-M3 is a class Ib MHC molecule of the mouse with a 10(4)-fold preference for
binding N-formylated peptides. To elucidate the basis of this unusual
specificity, we expressed and crystallized a soluble form of M3 with a
formylated nonamer peptide, fMYFINILTL, and determined the structure by X-ray
crystallography. M3, refined at 2.1 A resolution, resembles class la MHC
molecules in its overall structure, but differs in the peptide-binding groove.
The A pocket, which usually accommodates the free N-terminus of a bound peptide,
is closed, and the peptide is shifted one residue, such that the P1 side chain
is lodged in the B pocket. The formyl group is coordinated by His-9 and a bound
water on the floor of the groove.
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Secondary reference #1
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Title
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H-2m3 encodes the mhc class I molecule presenting the maternally transmitted antigen of the mouse.
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Authors
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C.R.Wang,
B.E.Loveland,
K.F.Lindahl.
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Ref.
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Cell, 1991,
66,
335-345.
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PubMed id
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