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PDBsum entry 1mcp
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Immunoglobulin
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PDB id
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1mcp
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Phosphocholine binding immunoglobulin FAB mcpc603. An X-Ray diffraction study at 2.7 a.
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Authors
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Y.Satow,
G.H.Cohen,
E.A.Padlan,
D.R.Davies.
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Ref.
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J Mol Biol, 1986,
190,
593-604.
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PubMed id
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Abstract
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The crystal structure of the Fab of McPC603, a phosphocholine-binding mouse
myeloma protein, has been refined at 2.7 A resolution by a combination of
restrained least-squares refinement and molecular modeling. The overall
structure remains as previously reported, with an elbow bend angle between the
variable and constant modules of 133 degrees. Some adjustments have been made in
the structure of the loops as a result of the refinement. The hypervariable
loops are all visible in the electron density map with the exception of three
residues in the first hypervariable loop of the light chain. A sulfate ion
occupies the site of binding of the phosphate moiety of phosphocholine.
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Secondary reference #1
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Title
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Kappa chain structure from a crystallized murine FAB': Role of joining segment in hapten binding.
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Authors
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S.Rudikoff,
Y.Satow,
E.Padlan,
D.Davies,
M.Potter.
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Ref.
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Mol Immunol, 1981,
18,
705-711.
[DOI no: ]
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PubMed id
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Secondary reference #2
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Title
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Immunoglobulin structures at high resolution.
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Authors
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D.R.Davies,
E.A.Padlan,
D.M.Segal.
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Ref.
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Contemp Top Mol Immunol, 1975,
4,
127-153.
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PubMed id
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Secondary reference #3
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Title
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The three-Dimensional structure of the antigen binding site of mcPC 603 protein
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Authors
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E.A.Padlan,
D.M.Segal,
G.H.Cohen,
D.R.Davies,
S.Rudikoff,
M.Potter.
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Ref.
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the immune system ...
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Secondary reference #4
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Title
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The three-Dimensional structure of a phosphorylcholine-Binding mouse immunoglobulin FAB and the nature of the antigen binding site.
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Authors
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D.M.Segal,
E.A.Padlan,
G.H.Cohen,
S.Rudikoff,
M.Potter,
D.R.Davies.
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Ref.
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Proc Natl Acad Sci U S A, 1974,
71,
4298-4302.
[DOI no: ]
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PubMed id
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Secondary reference #5
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Title
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Structure at 4.5 a resolution of a phosphorylcholine-Binding FAB.
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Authors
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E.A.Padlan,
D.M.Segal,
T.F.Spande,
D.R.Davies,
S.Rudikoff,
M.Potter.
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Ref.
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Nat New Biol, 1973,
245,
165-167.
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PubMed id
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Secondary reference #6
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Title
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Crystals of phosphorylcholine-Binding FAB-Fragments from mouse myeloma proteins: preparation and X-Ray analysis.
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Authors
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S.Rudikoff,
M.Potter,
D.M.Segal,
E.A.Padlan,
D.R.Davies.
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Ref.
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Proc Natl Acad Sci U S A, 1972,
69,
3689-3692.
[DOI no: ]
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PubMed id
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