UniProt functional annotation for P06876



	UniProt functional annotation for P06876

UniProt code: P06876.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Subunit: Binds to HIPK1 (By similarity). Interacts with HIPK2, MAF, MYBBP1A and NLK. {ECO:0000250, ECO:0000269|PubMed:11792321, ECO:0000269|PubMed:15082531, ECO:0000269|PubMed:17823980, ECO:0000269|PubMed:9447996, ECO:0000269|PubMed:9566892}.

Subcellular location: Nucleus.

Domain: Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.

Domain: C-terminal truncated mutants display increased transactivation.

Ptm: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. {ECO:0000250}.

Ptm: Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.

Ptm: Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels (By similarity). {ECO:0000250}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.


Subunit:		Binds to HIPK1 (By similarity). Interacts with HIPK2, MAF, MYBBP1A and NLK. {ECO:0000250, ECO:0000269\|PubMed:11792321, ECO:0000269\|PubMed:15082531, ECO:0000269\|PubMed:17823980, ECO:0000269\|PubMed:9447996, ECO:0000269\|PubMed:9566892}.
Subcellular location:		Nucleus.
Domain:		Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
Domain:		C-terminal truncated mutants display increased transactivation.
Ptm:		Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. {ECO:0000250}.
Ptm:		Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Ptm:		Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels (By similarity). {ECO:0000250}.