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PDBsum entry 1mbe
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DNA binding protein
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PDB id
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1mbe
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References listed in PDB file
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Key reference
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Title
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Comparison of the free and DNA-Complexed forms of the DNA-Binding domain from c-Myb.
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Authors
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K.Ogata,
S.Morikawa,
H.Nakamura,
H.Hojo,
S.Yoshimura,
R.Zhang,
S.Aimoto,
Y.Ametani,
Z.Hirata,
A.Sarai.
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Ref.
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Nat Struct Biol, 1995,
2,
309-320.
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PubMed id
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Abstract
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The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1,
R2 and R3). The three repeats have similar overall architectures, each
containing a helix-turn-helix variation motif. The three conserved tryptophans
in each repeat participate in forming a hydrophobic core. Comparison of the
three repeat structures indicated that cavities are found in the hydrophobic
core of R2, which is thermally unstable. On complexation with DNA, the
orientations of R2 and R3 are fixed by tight binding and their conformations are
slightly changed. No significant changes occur in the chemical shifts of R1
consistent with its loose interaction with DNA.
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Secondary reference #1
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Title
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Solution structure of a specific DNA complex of the myb DNA-Binding domain with cooperative recognition helices.
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Authors
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K.Ogata,
S.Morikawa,
H.Nakamura,
A.Sekikawa,
T.Inoue,
H.Kanai,
A.Sarai,
S.Ishii,
Y.Nishimura.
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Ref.
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Cell, 1994,
79,
639-648.
[DOI no: ]
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PubMed id
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Secondary reference #2
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Title
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Solution structure of a DNA-Binding unit of myb: a helix-Turn-Helix-Related motif with conserved tryptophans forming a hydrophobic core.
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Authors
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K.Ogata,
H.Hojo,
S.Aimoto,
T.Nakai,
H.Nakamura,
A.Sarai,
S.Ishii,
Y.Nishimura.
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Ref.
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Proc Natl Acad Sci U S A, 1992,
89,
6428-6432.
[DOI no: ]
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PubMed id
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