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PDBsum entry 1m4k
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Immune system
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PDB id
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1m4k
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Contents |
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* Residue conservation analysis
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PDB id:
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Immune system
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Title:
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Crystal structure of the human natural killer cell activator receptor kir2ds2 (cd158j)
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Structure:
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Killer cell immunoglobulin-like receptor 2ds2. Chain: a. Synonym: kir2ds2, mhc class i nk cell receptor, natural killer associated transcript 5, nkat-5, p58 natural killer cell receptor clone cl-49, p58 nk receptor, nk receptor 183 acti. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.30Å
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R-factor:
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0.221
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R-free:
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0.247
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Authors:
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X.Saulquin,L.N.Gastinel,E.Vivier
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Key ref:
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X.Saulquin
et al.
(2003).
Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j).
J Exp Med,
197,
933-938.
PubMed id:
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Date:
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03-Jul-02
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Release date:
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15-Apr-03
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PROCHECK
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Headers
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References
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P43631
(KI2S2_HUMAN) -
Killer cell immunoglobulin-like receptor 2DS2 from Homo sapiens
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Seq:
Struc:
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304 a.a.
193 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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J Exp Med
197:933-938
(2003)
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PubMed id:
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Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j).
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X.Saulquin,
L.N.Gastinel,
E.Vivier.
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ABSTRACT
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Killer cell Ig-like receptors (KIRs) regulate the function of human natural
killer and T cell subsets. A feature of the KIR locus is the clustering of
homologous genes encoding for inhibitory and activating KIR. Inhibitory and
activating KIR differ for ligand specificities and/or affinities. In particular,
we show here with KIR tetramers that activating KIR2DS2 does not bind HLA-Cw3
molecules recognized by inhibitory KIR2DL2, despite 99% extracellular amino acid
identity. We also report the 2.3-A structure of KIR2DS2, which reveals subtle
displacements of two residues (Tyr45 and Gln71) involved in the interaction of
KIR2DL2 with HLA-Cw3. These results show that KIR molecules cannot tolerate any
variability in their three-dimensional structure without altering their MHC
class I recognition capacities. Therefore, the mode of recognition used by KIR
largely differs from the conformational changes that characterize T cell
receptor or NKG2D interaction with their respective ligands.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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P.Parham,
and
A.Moffett
(2013).
Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution.
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Nat Rev Immunol,
13,
133-144.
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R.M.Faridi,
and
S.Agrawal
(2011).
Killer immunoglobulin-like receptors (KIRs) and HLA-C allorecognition patterns implicative of dominant activation of natural killer cells contribute to recurrent miscarriages.
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Hum Reprod,
26,
491-497.
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J.van Bergen,
and
F.Koning
(2010).
The tortoise and the hare: slowly evolving T-cell responses take hastily evolving KIR.
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Immunology,
131,
301-309.
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A.K.Purdy,
and
K.S.Campbell
(2009).
Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR).
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Cancer Biol Ther,
8,
2211-2220.
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C.J.VandenBussche,
T.J.Mulrooney,
W.R.Frazier,
S.Dakshanamurthy,
and
C.K.Hurley
(2009).
Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule.
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Genes Immun,
10,
162-173.
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G.David,
M.Morvan,
K.Gagne,
N.Kerdudou,
C.Willem,
A.Devys,
M.Bonneville,
G.Folléa,
J.D.Bignon,
and
C.Retière
(2009).
Discrimination between the main activating and inhibitory killer cell immunoglobulin-like receptor positive natural killer cell subsets using newly characterized monoclonal antibodies.
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Immunology,
128,
172-184.
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T.Graef,
A.K.Moesta,
P.J.Norman,
L.Abi-Rached,
L.Vago,
A.M.Older Aguilar,
M.Gleimer,
J.A.Hammond,
L.A.Guethlein,
D.A.Bushnell,
P.J.Robinson,
and
P.Parham
(2009).
KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.
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J Exp Med,
206,
2557-2572.
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PDB code:
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A.Velardi,
L.Ruggeri,
A.Mancusi,
E.Burchielli,
K.Perruccio,
F.Aversa,
and
M.F.Martelli
(2008).
Clinical impact of natural killer cell reconstitution after allogeneic hematopoietic transplantation.
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Semin Immunopathol,
30,
489-503.
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O.Hershkovitz,
A.Zilka,
A.Bar-Ilan,
S.Abutbul,
A.Davidson,
M.Mazzon,
B.M.Kümmerer,
A.Monsoengo,
M.Jacobs,
and
A.Porgador
(2008).
Dengue virus replicon expressing the nonstructural proteins suffices to enhance membrane expression of HLA class I and inhibit lysis by human NK cells.
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J Virol,
82,
7666-7676.
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G.M.Gillespie,
A.Bashirova,
T.Dong,
D.W.McVicar,
S.L.Rowland-Jones,
and
M.Carrington
(2007).
Lack of KIR3DS1 binding to MHC class I Bw4 tetramers in complex with CD8+ T cell epitopes.
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AIDS Res Hum Retroviruses,
23,
451-455.
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K.Kunert,
M.Seiler,
M.F.Mashreghi,
K.Klippert,
C.Schönemann,
K.Neumann,
J.Pratschke,
P.Reinke,
H.D.Volk,
and
K.Kotsch
(2007).
KIR/HLA ligand incompatibility in kidney transplantation.
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Transplantation,
84,
1527-1533.
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A.A.Bashirova,
M.P.Martin,
D.W.McVicar,
and
M.Carrington
(2006).
The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense.
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Annu Rev Genomics Hum Genet,
7,
277-300.
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C.Turesson,
D.J.Schaid,
C.M.Weyand,
L.T.Jacobsson,
J.J.Goronzy,
I.F.Petersson,
S.A.Dechant,
B.M.Nyähll-Wåhlin,
L.Truedsson,
G.Sturfelt,
and
E.L.Matteson
(2006).
Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis.
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Arthritis Rheum,
54,
2776-2783.
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L.Deng,
and
R.A.Mariuzza
(2006).
Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors.
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Semin Immunol,
18,
159-166.
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L.Ruggeri,
A.Mancusi,
E.Burchielli,
K.Perruccio,
F.Aversa,
M.F.Martelli,
and
A.Velardi
(2006).
Natural killer cell recognition of missing self and haploidentical hematopoietic transplantation.
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Semin Cancer Biol,
16,
404-411.
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L.Ruggeri,
F.Aversa,
M.F.Martelli,
and
A.Velardi
(2006).
Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self.
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Immunol Rev,
214,
202-218.
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S.S.Farag,
and
M.A.Caligiuri
(2006).
Human natural killer cell development and biology.
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Blood Rev,
20,
123-137.
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C.A.Stewart,
F.Laugier-Anfossi,
F.Vély,
X.Saulquin,
J.Riedmuller,
A.Tisserant,
L.Gauthier,
F.Romagné,
G.Ferracci,
F.A.Arosa,
A.Moretta,
P.D.Sun,
S.Ugolini,
and
E.Vivier
(2005).
Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.
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Proc Natl Acad Sci U S A,
102,
13224-13229.
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K.L.Hershberger,
J.Kurian,
B.T.Korber,
and
N.L.Letvin
(2005).
Killer cell immunoglobulin-like receptors (KIR) of the African-origin sabaeus monkey: evidence for recombination events in the evolution of KIR.
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Eur J Immunol,
35,
922-935.
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L.Abi-Rached,
and
P.Parham
(2005).
Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues.
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J Exp Med,
201,
1319-1332.
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P.Parham
(2005).
MHC class I molecules and KIRs in human history, health and survival.
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Nat Rev Immunol,
5,
201-214.
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R.Biassoni,
and
N.Dimasi
(2005).
Human natural killer cell receptor functions and their implication in diseases.
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Expert Rev Clin Immunol,
1,
405-417.
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T.Momot,
S.Koch,
N.Hunzelmann,
T.Krieg,
K.Ulbricht,
R.E.Schmidt,
and
T.Witte
(2004).
Association of killer cell immunoglobulin-like receptors with scleroderma.
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Arthritis Rheum,
50,
1561-1565.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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Links
