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UniProt functional annotation for P60568 | ||
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| UniProt codes: P60568, P01585. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. |
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| Subcellular location: | |
Secreted. |
| Disease: | |
Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. {ECO:0000269|PubMed:1396583}. |
| Pharmaceutical: | |
Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma. |
| Similarity: | |
Belongs to the IL-2 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA59140.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.