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PDBsum entry 1m0r
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Transferase PDB id
1m0r

 

 

 

 

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Contents
Protein chain
120 a.a.
Theoretical model
PDB id:
1m0r
Name: Transferase
Title: Homology model of dot1p
Structure: Dot1p histone methyltransferase. Chain: a. Fragment: residues 392-511. Synonym: ydr440w
Source: Saccharomyces cerevisiae. Yeast
Authors: M.Dlakic
Key ref: M.Dlakić (2001). Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold. Trends Biochem Sci, 26, 405-407. PubMed id: 11440840
Date:
14-Jun-02     Release date:   10-Jul-02    
PROCHECK
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 Headers
 References

Protein chain
No UniProt id for this chain
Struc: 120 a.a.
Key:    Secondary structure

 

 
Trends Biochem Sci 26:405-407 (2001)
PubMed id: 11440840  
 
 
Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold.
M.Dlakić.
 
  ABSTRACT  
 
Although protein methylation has been observed for decades, its functional significance has remained largely unclear. Using sensitive profile searches and structural modeling, chromatin silencing protein and meiotic recombination checkpoint regulator Dot1p was identified as a putative protein methyltransferase. Along with recent results that link histone H3 methylation with chromatin silencing, this finding suggests that an expanded combinatorial repertoire of protein modifications affects transcriptional regulation.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21243718 F.Frederiks, I.J.Stulemeijer, H.Ovaa, and F.van Leeuwen (2011).
A modified epigenetics toolbox to study histone modifications on the nucleosome core.
  Chembiochem, 12, 308-313.  
  18806472 I.M.Fingerman, H.N.Du, and S.D.Briggs (2008).
Controlling histone methylation via trans-histone pathways.
  Epigenetics, 3, 237-242.  
17675446 I.M.Fingerman, H.C.Li, and S.D.Briggs (2007).
A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway.
  Genes Dev, 21, 2018-2029.  
17374386 X.Cheng, and X.Zhang (2007).
Structural dynamics of protein lysine methylation and demethylation.
  Mutat Res, 618, 102-115.  
16714444 E.L.Mersfelder, and M.R.Parthun (2006).
The tale beyond the tail: histone core domain modifications and the regulation of chromatin structure.
  Nucleic Acids Res, 34, 2653-2662.  
15869391 X.Cheng, R.E.Collins, and X.Zhang (2005).
Structural and sequence motifs of protein (histone) methylation enzymes.
  Annu Rev Biophys Biomol Struct, 34, 267-294.  
15292170 K.Sawada, Z.Yang, J.R.Horton, R.E.Collins, X.Zhang, and X.Cheng (2004).
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase.
  J Biol Chem, 279, 43296-43306.
PDB code: 1u2z
12628190 J.Min, Q.Feng, Z.Li, Y.Zhang, and R.M.Xu (2003).
Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase.
  Cell, 112, 711-723.
PDB code: 1nw3
12672489 K.Luger (2003).
Structure and dynamic behavior of nucleosomes.
  Curr Opin Genet Dev, 13, 127-135.  
12142001 A.U.Khan, and M.Hampsey (2002).
Connecting the DOTs: covalent histone modifications and the formation of silent chromatin.
  Trends Genet, 18, 387-389.  
12086673 F.van Leeuwen, P.R.Gafken, and D.E.Gottschling (2002).
Dot1p modulates silencing in yeast by methylation of the nucleosome core.
  Cell, 109, 745-756.  
12080090 H.H.Ng, Q.Feng, H.Wang, H.Erdjument-Bromage, P.Tempst, Y.Zhang, and K.Struhl (2002).
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
  Genes Dev, 16, 1518-1527.  
12097318 N.Lacoste, R.T.Utley, J.M.Hunter, G.G.Poirier, and J.Côte (2002).
Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.
  J Biol Chem, 277, 30421-30424.  
12152067 S.D.Briggs, T.Xiao, Z.W.Sun, J.A.Caldwell, J.Shabanowitz, D.F.Hunt, C.D.Allis, and B.D.Strahl (2002).
Gene silencing: trans-histone regulatory pathway in chromatin.
  Nature, 418, 498.  
11917007 Y.Huang (2002).
Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.
  Nucleic Acids Res, 30, 1465-1482.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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