UniProt functional annotation for P23869

UniProt code: P23869.

Organism: Escherichia coli (strain K12).
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
 
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
 
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation: Inhibition by cyclosporin A with a Ki of 25 to 50 mu-mol, a concentration 100-fold higher than that required for eukaryotic PPIases.
Subcellular location: Cytoplasm.
Similarity: Belongs to the cyclophilin-type PPIase family.
Similarity: Contains 1 PPIase cyclophilin-type domain.

Annotations taken from UniProtKB at the EBI.