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UniProt functional annotation for P40937 | ||
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| UniProt code: P40937. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. {ECO:0000269|PubMed:8999859}. |
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| Subunit: | |
Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. {ECO:0000269|PubMed:11572977, ECO:0000269|PubMed:8999859}. |
| Subcellular location: | |
Nucleus {ECO:0000305}. |
| Similarity: | |
Belongs to the activator 1 small subunits family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.