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UniProt functional annotation for O57413 | ||
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| UniProt code: O57413. |
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| Organism: | |
Protobothrops mucrosquamatus (Taiwan habu) (Trimeresurus mucrosquamatus). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops. |
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| Function: | |
[Snake venom metalloproteinase TM-3]: Potent fibrinogenolytic protease which cleaves mainly the Aalpha chain of fibrinogen (FGA) and slightly the Bbeta (FGB) and the gamma (FGG) chains (PubMed:8193588, PubMed:7488093). May possess hemorrhagic activity (PubMed:7488093). Compared to other SVMP, the substrate-binding pocket is relatively shallow (PubMed:12077431). Is less susceptible to tripeptide inhibitors than TM-1 (AC U3KRG1) and TM-2 (PubMed:9703966). {ECO:0000269|PubMed:12077431, ECO:0000269|PubMed:7488093, ECO:0000269|PubMed:8193588, ECO:0000269|PubMed:9703966}. |
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| Function: | |
[Disintegrin trimucrin]: inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). {ECO:0000250|UniProtKB:P17349}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305|PubMed:12071970, ECO:0000305|PubMed:12077431}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:12071970, ECO:0000269|PubMed:12077431}; |
| Activity regulation: | |
Inhibited by EDTA and 1,10-phenanthroline (PubMed:8193588). Is also inhibited by endogenous tripeptide inhibitors pyroGlu-Asn-Trp, pyroGlu-Gln-Trp, and pyroGlu-Lys-Trp (PubMed:9703966, PubMed:12071970). {ECO:0000269|PubMed:12071970, ECO:0000269|PubMed:8193588, ECO:0000269|PubMed:9703966}. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:7488093, ECO:0000269|PubMed:8193588}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:7488093, ECO:0000269|PubMed:8193588}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:7488093, ECO:0000305|PubMed:8193588}. |
| Ptm: | |
The N-terminus is blocked. {ECO:0000269|PubMed:7488093}. |
| Miscellaneous: | |
This disintegrin is 100% identical to the disintegrin of AC E9NW27, another disintegrin of the P-II subfamily of Protobothrops mucrosquamatus. |
| Miscellaneous: | |
The disintegrin belongs to the medium disintegrin subfamily. |
| Similarity: | |
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA62600.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.