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UniProt functional annotation for P59071 | ||
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| UniProt code: P59071. |
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| Organism: | |
Daboia russelii (Russel's viper) (Vipera russelii). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Viperinae; Daboia. |
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| Function: | |
Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn- phosphoglycerides. {ECO:0000269|PubMed:18062812, ECO:0000269|PubMed:2115497, ECO:0000269|PubMed:8835338}. |
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| Catalytic activity: | |
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269|PubMed:16596639}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305|Ref.12}; Note=Binds 1 Ca(2+) ion. {ECO:0000305|Ref.12}; |
| Activity regulation: | |
Oxyphenbutazone (OPB), anisic acid and atropine inhibit the enzymatic activity by binding at the substrate-binding site (PubMed:15544328, PubMed:16596639). P-coumaric acid, resveratrol, spermidine, corticosterone and gramine derivative inhibit the enzymatic activity by binding at the substrate-binding site (PubMed:25541253). {ECO:0000269|PubMed:15544328, ECO:0000269|PubMed:16596639, ECO:0000269|PubMed:25541253}. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:16596639, ECO:0000269|PubMed:7940574}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:20203422, ECO:0000269|PubMed:7940574, ECO:0000269|PubMed:8835338}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:20203422, ECO:0000305|PubMed:7940574, ECO:0000305|PubMed:8835338}. |
| Toxic dose: | |
LD(50) is between 5.3 and 5.5 mg/kg by intravenous injection into mice. {ECO:0000269|PubMed:2718191, ECO:0000269|PubMed:8835338}. |
| Miscellaneous: | |
D.russelli pulchella is synonymous with D.russelii. {ECO:0000305|PubMed:15544328, ECO:0000305|PubMed:16596639}. |
| Similarity: | |
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.