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UniProt functional annotation for P28676 | ||
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| UniProt code: P28676. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions. |
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| Subunit: | |
Homodimer. Interacts with SRI and LCP1. {ECO:0000269|PubMed:11279160, ECO:0000269|PubMed:11717497, ECO:0000269|PubMed:12804766, ECO:0000269|PubMed:1530588}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:1530588, ECO:0000269|PubMed:1737748}. Cytoplasmic granule membrane {ECO:0000269|PubMed:1737748, ECO:0000305|PubMed:1530588}; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels. {ECO:0000269|PubMed:1737748}. |
| Tissue specificity: | |
Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow. {ECO:0000269|PubMed:1737748}. |
| Miscellaneous: | |
This protein has been shown to bind calcium with high affinity. |
| Sequence caution: | |
Sequence=BAD93005.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.