PDBsum entry 1jwo

Transferase

PDB id: 1jwo

Contents

Protein chain

97 a.a. *

Waters ×48

* Residue conservation analysis

PDB id:

1jwo

Name:

Transferase

Title:

Crystal structure analysis of the sh2 domain of the csk homologous kinase chk

Structure:

Csk homologous kinase. Chain: a. Fragment: sh2 domain. Synonym: chk, megakaryocyte-associated tyrosine-protein kinase, tyrosine-protein kinase ctk, protein kinase hyl, hematopoietic consensus tyrosine-lacking kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: matk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.50Å R-factor: 0.194 R-free: 0.257

Authors:

T.V.S.Murthy,G.D.Webster

Key ref:

T.V.S.Murthy and g.d.webster Recognition of the her-2/neu receptor by the sh2 domain of the csk homologous kinase. To be published, .

Date:

04-Sep-01 Release date: 12-Sep-01

Protein chain

P42679  (MATK_HUMAN) -  Megakaryocyte-associated tyrosine-protein kinase from Homo sapiens

Seq: 507 a.a.

Struc: 97 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site