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PDBsum entry 1jr4

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Transferase PDB id
1jr4
Jmol
Contents
Protein chain
212 a.a. *
Ligands
CL4
Metals
_MG
Waters ×16
* Residue conservation analysis

References listed in PDB file
Key reference
Title X-Ray crystal structure of a bisubstrate inhibitor bound to the enzyme catechol-O-Methyltransferase: a dramatic effect of inhibitor preorganization on binding affinity we thank f. Hoffmann-La roche for generous support of this work. We are grateful to p. Malherbe for the cloning of comt, P. Caspers for the expression of comt, A. Cesura for enzyme purification, B. Wipf for fermentation, And h. W. Lahm for sequencing.
Authors C.Lerner, A.Ruf, V.Gramlich, B.Masjost, G.Z?rcher, R.Jakob-Roetne, E.Borroni, F.Diederich.
Ref. Angew Chem Int Ed Engl, 2001, 40, 4040-4042.
PubMed id 12404486
Abstract
No abstract given.
Secondary reference #1
Title Structure-Based design, Synthesis, And in vitro evaluation of bisubstrate inhibitors for catechol o-Methyltransferase (comt).
Authors B.Masjost, P.Ballmer, E.Borroni, G.Zürcher, F.K.Winkler, R.Jakob-Roetne, F.Diederich.
Ref. Chemistry, 2000, 6, 971-982.
PubMed id 10785817
Abstract
PROCHECK
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 Headers