UniProt functional annotation for Q92956



	UniProt functional annotation for Q92956

UniProt code: Q92956.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044) (By similarity). {ECO:0000250|UniProtKB:Q80WM9, ECO:0000269|PubMed:10754304, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19915044, ECO:0000269|PubMed:23761635, ECO:0000269|PubMed:9153189, ECO:0000269|PubMed:9162022, ECO:0000269|PubMed:9462508}.

Function: (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.

Function: (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.

Subunit: Interacts with TRAF2, TRAF3 and TRAF5 (PubMed:9153189, PubMed:9162022). Interacts (via CRD1/TNFR-Cys 1) with CD160; this interaction is direct (PubMed:18193050, PubMed:23761635). Interacts with LTA and TNFSF14 (PubMed:9462508). Interacts (via CRD1/TNFR-Cys 1) in cis and trans with BTLA; the cis interactions inhibits the trans interactions (PubMed:19915044, PubMed:16169851). {ECO:0000269|PubMed:16169851, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19915044, ECO:0000269|PubMed:23761635, ECO:0000269|PubMed:9153189, ECO:0000269|PubMed:9162022, ECO:0000269|PubMed:9462508}.

Subunit: (Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.

Subunit: (Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19915044}; Single-pass type I membrane protein {ECO:0000305}.

Tissue specificity: Widely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044). {ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19915044}.

Domain: The cysteine rich domain I (CRD1/TNFR-Cys 1) is required for interaction with BY55 and BTLA. {ECO:0000269|PubMed:18193050}.

Ptm: N-glycosylated. {ECO:0000269|PubMed:16169851}.

Similarity: Belongs to the tumor necrosis factor receptor superfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044) (By similarity). {ECO:0000250\|UniProtKB:Q80WM9, ECO:0000269\|PubMed:10754304, ECO:0000269\|PubMed:18193050, ECO:0000269\|PubMed:19915044, ECO:0000269\|PubMed:23761635, ECO:0000269\|PubMed:9153189, ECO:0000269\|PubMed:9162022, ECO:0000269\|PubMed:9462508}.



Function:		(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. {ECO:0000269\|PubMed:11511370, ECO:0000269\|PubMed:9696799}.



Function:		(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. {ECO:0000269\|PubMed:11511370, ECO:0000269\|PubMed:9696799}.


Subunit:		Interacts with TRAF2, TRAF3 and TRAF5 (PubMed:9153189, PubMed:9162022). Interacts (via CRD1/TNFR-Cys 1) with CD160; this interaction is direct (PubMed:18193050, PubMed:23761635). Interacts with LTA and TNFSF14 (PubMed:9462508). Interacts (via CRD1/TNFR-Cys 1) in cis and trans with BTLA; the cis interactions inhibits the trans interactions (PubMed:19915044, PubMed:16169851). {ECO:0000269\|PubMed:16169851, ECO:0000269\|PubMed:18193050, ECO:0000269\|PubMed:19915044, ECO:0000269\|PubMed:23761635, ECO:0000269\|PubMed:9153189, ECO:0000269\|PubMed:9162022, ECO:0000269\|PubMed:9462508}.
Subunit:		(Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D. {ECO:0000269\|PubMed:11511370, ECO:0000269\|PubMed:9696799}.
Subunit:		(Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D. {ECO:0000269\|PubMed:11511370, ECO:0000269\|PubMed:9696799}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:19915044}; Single-pass type I membrane protein {ECO:0000305}.
Tissue specificity:		Widely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044). {ECO:0000269\|PubMed:18193050, ECO:0000269\|PubMed:19915044}.
Domain:		The cysteine rich domain I (CRD1/TNFR-Cys 1) is required for interaction with BY55 and BTLA. {ECO:0000269\|PubMed:18193050}.
Ptm:		N-glycosylated. {ECO:0000269\|PubMed:16169851}.
Similarity:		Belongs to the tumor necrosis factor receptor superfamily. {ECO:0000305}.