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UniProt functional annotation for P57083 | ||
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| UniProt code: P57083. |
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| Organism: | |
Human herpesvirus 1 (strain Patton) (HHV-1) (Human herpes simplex virus 1). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus. |
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| Function: | |
Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, NECTIN1 and 3-O-sulfated heparan sulfate. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity). {ECO:0000250}. |
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| Subunit: | |
Homodimer (By similarity). Interacts with host receptor TNFRSF14. Interacts with host receptor NECTIN1. Interacts (via profusion domain) with gB; this interaction occurs in the absence of gH/gL. Interacts (via profusion domain) with gH/gL heterodimer; this interaction occurs in the absence of gB. Associates with the gB-gH/gL- gD complex. Interacts (via C-terminus) with UL11 tegument protein. Interacts with host RSAD2 (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Virion membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Host Golgi apparatus {ECO:0000250|UniProtKB:Q69091}. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. {ECO:0000250}. |
| Similarity: | |
Belongs to the herpesviridae glycoprotein D family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.