UniProt functional annotation for Q62132



	UniProt functional annotation for Q62132

UniProt code: Q62132.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton. {ECO:0000269|PubMed:10601328, ECO:0000269|PubMed:10949045}.

Catalytic activity: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE- ProRule:PRU10044};

Subunit: Interacts with MAPKs. {ECO:0000269|PubMed:10601328}.

Subcellular location: [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.

Subcellular location: [Isoform Beta]: Cytoplasm. Note=Locates to the areas within the cytoplasm.

Subcellular location: [Isoform Gamma]: Cytoplasm. Note=Locates to the areas within the cytoplasm.

Tissue specificity: Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform alpha is expressed throughout the granular layer of the cerebellar but not within the Purkinje cells, also in the villi of the ileum and jejunum and both the villi and crypts of the duodenum. Isoform beta is expressed only in the Purkinje cells. Isoform gamma is expressed throughout the brain, the villi and crypts of the duodenum, jejunum and ileum and expressed at low levels in the proximal colon. {ECO:0000269|PubMed:10705342, ECO:0000269|PubMed:10949045, ECO:0000269|PubMed:7832766, ECO:0000269|PubMed:7836467}.

Developmental stage: Isoform gamma is the only family member developmentally expressed. Expressed throughout the brain in 15.5 day embryos and in cranial nerve cells, skeletal tissues such as neural crest-derived face bones, and the periphery of cartilaginous skeletal elements including the rib and vertebrae anlage. On day 17.5, expression was observed throughout the brain, trigeminal ganglion, cranofacial bones, oral-facial structures, cervical vertebrae, axis and the ileum. Expression continued in the vertebral column throughout ossification. {ECO:0000269|PubMed:10949045}.

Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. {ECO:0000305}.

Sequence caution: Sequence=CAA82958.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton. {ECO:0000269\|PubMed:10601328, ECO:0000269\|PubMed:10949045}.


Catalytic activity:		Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255\|PROSITE- ProRule:PRU10044};
Subunit:		Interacts with MAPKs. {ECO:0000269\|PubMed:10601328}.
Subcellular location:		[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.
Subcellular location:		[Isoform Beta]: Cytoplasm. Note=Locates to the areas within the cytoplasm.
Subcellular location:		[Isoform Gamma]: Cytoplasm. Note=Locates to the areas within the cytoplasm.
Tissue specificity:		Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform alpha is expressed throughout the granular layer of the cerebellar but not within the Purkinje cells, also in the villi of the ileum and jejunum and both the villi and crypts of the duodenum. Isoform beta is expressed only in the Purkinje cells. Isoform gamma is expressed throughout the brain, the villi and crypts of the duodenum, jejunum and ileum and expressed at low levels in the proximal colon. {ECO:0000269\|PubMed:10705342, ECO:0000269\|PubMed:10949045, ECO:0000269\|PubMed:7832766, ECO:0000269\|PubMed:7836467}.
Developmental stage:		Isoform gamma is the only family member developmentally expressed. Expressed throughout the brain in 15.5 day embryos and in cranial nerve cells, skeletal tissues such as neural crest-derived face bones, and the periphery of cartilaginous skeletal elements including the rib and vertebrae anlage. On day 17.5, expression was observed throughout the brain, trigeminal ganglion, cranofacial bones, oral-facial structures, cervical vertebrae, axis and the ileum. Expression continued in the vertebral column throughout ossification. {ECO:0000269\|PubMed:10949045}.
Similarity:		Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. {ECO:0000305}.
Sequence caution:		Sequence=CAA82958.1; Type=Erroneous initiation; Evidence={ECO:0000305};