|
|
||
|
|
|
|
|
UniProt functional annotation for P0A7C2 | ||
|
|
|
|
|
|
||
| UniProt codes: P0A7C2, P03033. |
|
||
| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
|
||
|
||
| Function: | |
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352). {ECO:0000255|HAMAP-Rule:MF_00015, ECO:0000269|PubMed:20005847, ECO:0000269|PubMed:22412352, ECO:0000269|PubMed:7027255, ECO:0000269|PubMed:7027256}. |
|
||
| Catalytic activity: | |
Reaction=Hydrolysis of Ala-|-Gly bond in repressor LexA.; EC=3.4.21.88; Evidence={ECO:0000255|HAMAP-Rule:MF_00015}; |
| Subunit: | |
Homodimer. |
| Similarity: | |
Belongs to the peptidase S24 family. {ECO:0000255|HAMAP- Rule:MF_00015}. |
Annotations taken from UniProtKB at the EBI.