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UniProt functional annotation for P51177 | ||
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| UniProt code: P51177. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (PubMed:7665624). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:9651312). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). {ECO:0000250|UniProtKB:Q8VBV8, ECO:0000269|PubMed:7665624, ECO:0000269|PubMed:9651312}. |
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| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:7665624}; Lipid-anchor {ECO:0000269|PubMed:7665624}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:7665624, ECO:0000269|PubMed:9620085}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250|UniProtKB:Q8VBV8}. |
| Tissue specificity: | |
In the retina, expressed in rod and cone photoreceptor cells. Appears to be more abundant in rods. {ECO:0000269|PubMed:9620085}. |
| Ptm: | |
The N-terminus is blocked. |
| Miscellaneous: | |
Binds three calcium ions. |
Annotations taken from UniProtKB at the EBI.