UniProt functional annotation for Q47450



	UniProt functional annotation for Q47450

UniProt code: Q47450.

Organism: Escherichia coli.

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Tip adhesin component of type P pili that plays a critical role in kidney infection through targeted interaction with the globoseries glycolipids containing the Gal-alpha(1-4)-Gal disaccharide present on uroepithelial cells (PubMed:11440716, PubMed:31361021). In turn, transcriptionally regulates host gene expression in kidney cells, leading to inflammatory pathway activation and renal tissue damage. Acts thereby as key determinant of invasive uropathogenic E.coli (UPEC), which cause pyelonephritis and urinary-source bacteremia (By similarity). {ECO:0000250|UniProtKB:A0A0H2VAQ6, ECO:0000269|PubMed:11440716, ECO:0000269|PubMed:31361021}.

Subcellular location: Secreted {ECO:0000250|UniProtKB:P13720}. Fimbrium {ECO:0000250|UniProtKB:P13720}. Note=At the tip of P pili. {ECO:0000250|UniProtKB:P13720}.

Miscellaneous: Strains of E.coli that cause infection of the human urinary tract produce pap-pili (P pili) which are hair-like appendages consisting of about 1000 helically arranged subunits of the protein PapA. These pili mediate binding to digalactoside-containing glycolipids present on the epithelial cells which line the urinary tract.

Similarity: Belongs to the adhesin PapG family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli.
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Tip adhesin component of type P pili that plays a critical role in kidney infection through targeted interaction with the globoseries glycolipids containing the Gal-alpha(1-4)-Gal disaccharide present on uroepithelial cells (PubMed:11440716, PubMed:31361021). In turn, transcriptionally regulates host gene expression in kidney cells, leading to inflammatory pathway activation and renal tissue damage. Acts thereby as key determinant of invasive uropathogenic E.coli (UPEC), which cause pyelonephritis and urinary-source bacteremia (By similarity). {ECO:0000250\|UniProtKB:A0A0H2VAQ6, ECO:0000269\|PubMed:11440716, ECO:0000269\|PubMed:31361021}.


Subcellular location:		Secreted {ECO:0000250\|UniProtKB:P13720}. Fimbrium {ECO:0000250\|UniProtKB:P13720}. Note=At the tip of P pili. {ECO:0000250\|UniProtKB:P13720}.
Miscellaneous:		Strains of E.coli that cause infection of the human urinary tract produce pap-pili (P pili) which are hair-like appendages consisting of about 1000 helically arranged subunits of the protein PapA. These pili mediate binding to digalactoside-containing glycolipids present on the epithelial cells which line the urinary tract.
Similarity:		Belongs to the adhesin PapG family. {ECO:0000305}.