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PDBsum entry 1itb
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Complex (immunoglobulin/receptor)
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PDB id
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1itb
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.
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Authors
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G.P.Vigers,
L.J.Anderson,
P.Caffes,
B.J.Brandhuber.
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Ref.
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Nature, 1997,
386,
190-194.
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PubMed id
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Abstract
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Interleukin-1 (IL-1) is an important mediator of inflammatory disease. The IL-1
family currently consists of two agonists, IL-1alpha and IL-1beta, and one
antagonist, IL-1ra. Each of these molecules binds to the type I IL-1 receptor
(IL1R). The binding of IL-1alpha or IL-1beta to IL1R is an early step in IL-1
signal transduction and blocking this interaction may therefore be a useful
target for the development of new drugs. Here we report the three-dimensional
structure of IL-1beta bound to the extracellular domain of IL1R (s-IL1R) at 2.5
A resolution. IL-1beta binds to s-IL1R with a 1:1 stoichiometry. The crystal
structure shows that s-IL1R consists of three immunoglobulin-like domains which
wrap around IL-1beta in a manner distinct from the structures of previously
described cytokine-receptor complexes. The two receptor-binding regions on
IL-1beta identified by site-directed mutagenesis both contact the receptor: one
binds to the first two domains of the receptor, while the other binds
exclusively to the third domain.
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