PDBsum entry 1iqh

Hydrolase

PDB id: 1iqh

Contents

Protein chains

235 a.a. *

51 a.a. *

Ligands

XMF

Metals

_CA

* Residue conservation analysis

PDB id:

1iqh

Name:

Hydrolase

Title:

Human coagulation factor xa in complex with m55143

Structure:

Coagulation factor xa. Chain: a. Fragment: heavy chain, catalytic domain (residues 235-469). Coagulation factor xa. Chain: l. Fragment: light chain, epidermal growth factor like domain (residues 84-179). Ec: 3.4.21.6

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606

Biol. unit:

Dimer (from PQS)

Resolution:

3.00Å R-factor: 0.177 R-free: 0.286

Authors:

I.Shiromizu,T.Matsusue

Key ref:

T.Matsusue et al. Factor xa specific inhibitor that induces the novel binding model in complex with human fxa. To be published, .

Date:

23-Jul-01 Release date: 23-Sep-03

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 235 a.a.

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 51 a.a.

Enzyme reactions

• Enzyme class: Chains A, L: E.C.3.4.21.6 - coagulation factor Xa.
• Reaction: Preferential cleavage: Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.