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UniProt functional annotation for P35070 | ||
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| UniProt code: P35070. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. {ECO:0000269|PubMed:8570211}. |
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| Subunit: | |
Monomer. Interacts with EGFR and ERBB4. {ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:8570211}. |
| Subcellular location: | |
[Betacellulin]: Secreted, extracellular space. |
| Subcellular location: | |
[Probetacellulin]: Cell membrane; Single-pass type I membrane protein. |
| Tissue specificity: | |
Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine. {ECO:0000269|PubMed:8919026}. |
Annotations taken from UniProtKB at the EBI.