PDBsum entry 1io6

Signaling protein

PDB id: 1io6

Contents

Protein chain

59 a.a. *

Ligands

ARG-HIS-TYR-ARG-PRO-LEU-PRO-PRO-LEU-PRO

* Residue conservation analysis

PDB id:

1io6

Name:

Signaling protein

Title:

Growth factor receptor-bound protein 2 (grb2) c-terminal sh3 domain complexed with a ligand peptide (nmr, minimized mean structure)

Structure:

Growth factor receptor-bound protein 2. Chain: a. Fragment: c-terminal sh3(residue 159-215). Synonym: grb2-c-sh3. Engineered: yes. A ligand peptide. Chain: b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: the peptide was chemically synthesized by the solid- phase fmoc strategy. The sequence of this peptide is artificial and is not naturally found.

NMR struc:

1 models

Authors:

M.Kawasaki,K.Ogura,H.Hatanaka,F.Inagaki

Key ref:

M.Kawasaki et al. Solution structure of the c-Terminal sh3 domain of grb2 complexed with a ligand peptide: a ligand exchange model of the sh3 domain. To be published, .

Date:

25-Jan-01 Release date: 14-Feb-01

Protein chain

P62993  (GRB2_HUMAN) -  Growth factor receptor-bound protein 2 from Homo sapiens

Seq: 217 a.a.

Struc: 59 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.?