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UniProt functional annotation for P25687 | ||
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| UniProt code: P25687. |
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| Organism: | |
Dendroaspis polylepis polylepis (Black mamba). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis. |
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| Function: | |
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2 (PubMed:12054613). Potently contracts gastrointestinal (GI) smooth muscle (PubMed:10567694). {ECO:0000269|PubMed:10567694, ECO:0000269|PubMed:12054613}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:10567694}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:10567694}. |
| Miscellaneous: | |
This toxin does not inhibit Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.4/KCNA4, Kv1.5/KCNA5, Kv2.1/KCNB1, Kv3.4/KCNC4, Kv4.2/KCND2, K2P2.1/KCNK2, Kv11/KCNH, Kv7.1/KCNQ1, Kv7.2/KCNQ2, Kv7.3/KCNQ3, Kir1.1/KCNJ1, Kir2.1/KCNJ2, Kir2.2/KCNJ12, Kir3.1/KCNJ3- Kir3.2/KCNJ6 (GIRK1,2) and Kir3.1/KCNJ3-Kir3.4/KCNJ5 (GIRK1,4). {ECO:0000269|PubMed:10567694}. |
| Similarity: | |
Belongs to the AVIT (prokineticin) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.