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UniProt functional annotation for P22029 | ||
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| UniProt code: P22029. |
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| Organism: | |
Bothrops jararaca (Jararaca) (Bothrops jajaraca). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops. |
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| Function: | |
Snaclec that binds to von Willebrand factor (VWF) and induces its interaction with GPIbalpha (GP1BA) (via the vWF A1 domain), resulting in platelet aggregation. |
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| Subunit: | |
Heterodimer of subunits alpha and beta; disulfide-linked. Botrocetin and vWF form a soluble complex. {ECO:0000269|PubMed:11148028, ECO:0000269|PubMed:12121649, ECO:0000269|PubMed:15665869, ECO:0000269|PubMed:8430107}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Biotechnology: | |
Is a standard reagent for testing vWF/platelet interactions and detection of the defects in von Willebrand disease and in GPIb-related disorders such as Bernard-Soulier syndrome. |
| Miscellaneous: | |
There are two distinct forms of the vWF-dependent platelet coagglutinin. The dimeric form (snaclec) is 34-fold more active than the metalloprotease botrocetin in promoting vWF binding to platelets (PubMed:1993206). {ECO:0000305|PubMed:1993206}. |
| Similarity: | |
Belongs to the snaclec family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.